Design and performance testing of an axial-flow ventricular assist device developed at the Fu Wai Hospital in Beijing.
Purpose: Various ventricular assist devices (VADs) have been developed for clinical use in recent years. The aim of a multidisciplinary research team at the Fuwai Hospital of the Peking Union Medical College is to design and develop an axial flow left ventricular assist device (LVAD) for adults.Meth...
| Publicado en: | International Journal of Artificial Organs Vol. 31; no. 11; pp. 983 - 988 |
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| Autores principales: | , , , , , , , , , , , , , , , , , , , |
| Formato: | research Journal Article |
| Publicado: |
Sage Publications Inc.
2008
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=105619624&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 105619624 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 03913988 50IJ jtl: International Journal of Artificial Organs issn: 03913988 maglogo: Y pubinfo: dt: 2008 vid: 31 iid: 11 pid: 344 pub: Sage Publications Inc. place: Thousand Oaks, California artinfo: ui: 105619624 NLM19089800 2010161849 10.1177/039139880803101108 NLM19089800 105619624 ppf: 983 ppct: 5 formats: tig: atl: Design and performance testing of an axial-flow ventricular assist device developed at the Fu Wai Hospital in Beijing. aug: au: Zhang Y Hu SS Zhou JY Sun HS Zhang H Zheng Z Zhu XD Li GR Gui XM Zhan Z Jin DH Zhang, Y Hu, S-S Zhou, J-Y Sun, H-S Zhang, H Zheng, Z Zhu, X-D Li, G-R Gui, X-M affil: Research Center for Cardiovascular Regenerative Medicine, Fu Wai Hospital, Beijing and Department of Cardiovascular Surgery, Fu Wai Hospital, Beijing - China sug: subj: Heart Assist Devices Adverse Effects Hemodynamics Adult Animals China Computer Simulation Computing Methodologies Hemolysis Materials Testing Models, Biological Prosthesis Design Sheep Thrombosis Etiology Adult: 19-44 years ab: Purpose: Various ventricular assist devices (VADs) have been developed for clinical use in recent years. The aim of a multidisciplinary research team at the Fuwai Hospital of the Peking Union Medical College is to design and develop an axial flow left ventricular assist device (LVAD) for adults.Methods: Using Computational Fluid Dynamics (CFD), the inflow characteristics of the axial flow pump were analyzed. After CFD analysis, the axial pump was fabricated using a 5-axis, computer numerical control (CNC) milling machine. Performances of the pump both in vitro and in vivo were tested.Results: This VAD, which was developed after numerous CFD analyses for the flow characteristics of the pump, is 58.5 mm long, 30 mm wide and weighs 120 g. The pump can deliver 5 lpm for pressures of 100 mmHg over 8500 rpm. The NIH value was 0.01 g/100 L. The hemolysis, which was evaluated in an in vivo test, was a bit higher than the normal value, but remained within an acceptable range.Conclusions: Performance of the pump in vitro and in vivo was considered sufficient for an LVAD. Further design improvements are being undertaken in terms of hemolysis and thrombosis to improve the biocompatibility of the pump. pubtype: Academic Journal doctype: research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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