T1rho, T2 and focal knee cartilage abnormalities in physically active and sedentary healthy subjects versus early OA patients--a 3.0-Tesla MRI study.
(1) To assess the degree of focal cartilage abnormalities in physically active and sedentary healthy subjects as well as in patients with early osteoarthritis (OA). (2) To determine the diagnostic value of T2 and T1rho measurements in identifying asymptomatic physically active subjects with focal ca...
| Publicado en: | European Radiology Vol. 19; no. 1; pp. 132 - 144 |
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| Autores principales: | , , , , , , , , , , , , , |
| Formato: | research Journal Article |
| Publicado: |
Springer Nature
Jan2009
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=105624559&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 105624559 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 09387994 NPH jtl: European Radiology issn: 09387994 maglogo: N pubinfo: dt: Jan2009 vid: 19 iid: 1 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 105624559 105624559 36145925 NLM18709373 2010167839 10.1007/s00330-008-1107-6 NLM18709373 105624559 ppf: 132 ppct: 12 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: T1rho, T2 and focal knee cartilage abnormalities in physically active and sedentary healthy subjects versus early OA patients--a 3.0-Tesla MRI study. aug: au: Stahl R Luke A Li X Carballido-Gamio J Ma CB Majumdar S Link TM Stahl, Robert Luke, Anthony Li, Xiaojuan Carballido-Gamio, Julio Ma, C Benjamin Majumdar, Sharmila Link, Thomas M affil: Department of Radiology, University of California, San Francisco, CA 94107-0946, USA sug: subj: Cartilage Diseases Pathology Cartilage, Articular Pathology Knee Joint Pathology Magnetic Resonance Imaging Methods Motor Activity Osteoarthritis Pathology Adult Cartilage Diseases Complications Female Male Middle Age Osteoarthritis Complications Relaxation Reproducibility of Results Sensitivity and Specificity Human Adult: 19-44 years Middle Aged: 45-64 years Female Male ab: (1) To assess the degree of focal cartilage abnormalities in physically active and sedentary healthy subjects as well as in patients with early osteoarthritis (OA). (2) To determine the diagnostic value of T2 and T1rho measurements in identifying asymptomatic physically active subjects with focal cartilage lesions. Thirteen asymptomatic physically active subjects, 7 asymptomatic sedentary subjects, and 17 patients with mild OA underwent 3.0-T MRI of the knee joint. T1rho and T2 values, cartilage volume and thickness, as well as the WORMS scores were obtained. Nine out of 13 active healthy subjects had focal cartilage abnormalities. T1rho and T2 values in active subjects with and without focal cartilage abnormalities differed significantly (p < 0.05). T1rho and T2 values were significantly higher (p < 0.05) in early OA patients compared to healthy subjects. T1rho measurements were superior to T2 in differentiating OA patients from healthy subjects, yet T1rho was moderately age-dependent. (1) Active subjects showed a high prevalence of focal cartilage abnormalities and (2) active subjects with and without focal cartilage abnormalities had different T1rho and T2 composition of cartilage. Thus, T1rho and T2 could be a parameter suited to identify active healthy subjects at higher risk for developing cartilage pathology. pubtype: Academic Journal doctype: research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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