Dynamic contrast-enhanced MRI of anterior prostate cancer: morphometric assessment and correlation with radical prostatectomy findings.
The purpose of the study was to relate morphometric features of prostate cancers in the anterior compartment of the prostate by dynamic contrast-enhanced (DCE) MRI to subsequent histopathologic findings. We prospectively performed DCE-MRI before biopsy in patients with suspected prostate cancer and...
| Publicado en: | European Radiology Vol. 19; no. 2; pp. 470 - 481 |
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| Autores principales: | , , , , , , , , , , , , , |
| Formato: | research Journal Article |
| Publicado: |
Springer Nature
Feb2009
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=105624997&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 105624997 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 09387994 NPH jtl: European Radiology issn: 09387994 maglogo: N pubinfo: dt: Feb2009 vid: 19 iid: 2 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 105624997 36145956 NLM18758786 2010168293 10.1007/s00330-008-1153-0 NLM18758786 105624997 ppf: 470 ppct: 11 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Dynamic contrast-enhanced MRI of anterior prostate cancer: morphometric assessment and correlation with radical prostatectomy findings. aug: au: Lemaitre L Puech P Poncelet E Bouyé S Leroy X Biserte J Villers A Lemaitre, Laurent Puech, Philippe Poncelet, Edouard Bouyé, Sébastien Leroy, Xavier Biserte, Jacques Villers, Arnauld affil: Department of Radiology, Centre Hospitalier Régional Universitaire de Lille, 59037 Lille Cedex, France sug: subj: Contrast Media Pharmacodynamics Magnetic Resonance Imaging Methods Prostatectomy Methods Prostatic Neoplasms Diagnosis Prostatic Neoplasms Pathology Aged Biopsy Image Processing, Computer Assisted Male Middle Age Oncology Methods Prostate Anatomy and Histology Prostate Pathology Prostatic Neoplasms Surgery Human Aged: 65+ years Middle Aged: 45-64 years Male ab: The purpose of the study was to relate morphometric features of prostate cancers in the anterior compartment of the prostate by dynamic contrast-enhanced (DCE) MRI to subsequent histopathologic findings. We prospectively performed DCE-MRI before biopsy in patients with suspected prostate cancer and selected those showing both a suspicious lesion at MRI and positive biopsies in the anterior compartment of the gland. Tumor contours, margins, largest surface areas and volumes were assessed at MRI and histopathology, when available. Anterior compartment tumors were classified according to transition zone (TZ) boundaries with the peripheral zone (PZ) or with the anterior fibromuscular stroma (SFMA). Forty-three patients were included in this study [median PSA 12.7 ng/ml (3.6-72)]. Whole-mount radical prostatectomy specimens were available in 27 cases. Of the anterior cancers, 89% had ill-defined margins at T2-weighted MRI. Cancer location and contour established at MRI agreed well with histopathology in the 27 cases. Median largest surface area and volume were 1.38 cm(2) (0.35-5.82) and 1.01 cc (0.15-7.4) for MRI versus 1.86 cm(2) (0.2-14) and 2.84 cc (0.33-28.92) for histopathology with respective correlation coefficients (r(2)) of 0.73 and 0.69. The site of origin could be accurately determined for the 15 tumors of less than 3 cc. We found a good relationship between DCE-MRI and histopathology for localization, morphologic description and volume assessment of anterior prostate cancers. pubtype: Academic Journal doctype: research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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