Dopamine vs noradrenaline: inverted-U effects and ADHD theories.
The aim of the present study was to review the dopamine theory of attention-deficit-hyperactivity disorder (ADHD), in light of recent use of noradrenergic therapies. A historical review of pharmacological theories of ADHD was conducted, including inverted-U, spatial working memory and neural circuit...
| Publicado en: | Australian & New Zealand Journal of Psychiatry Vol. 43; no. 2; pp. 101 - 109 |
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| Autor principal: | |
| Formato: | research Journal Article |
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Sage Publications Inc.
Feb2009
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=105631169&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 105631169 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 00048674 7ZU jtl: Australian & New Zealand Journal of Psychiatry issn: 00048674 maglogo: Y pubinfo: dt: Feb2009 vid: 43 iid: 2 pid: 344 pub: Sage Publications Inc. place: Thousand Oaks, California artinfo: ui: 105631169 2010171553 10.1080/00048670802607238 NLM19153917 105631169 ppf: 101 ppct: 8 formats: fmt: @attributes: type: P tig: atl: Dopamine vs noradrenaline: inverted-U effects and ADHD theories. aug: au: Levy F affil: School of Psychiatry, University of New South Wales Head, Child and Family East, Prince of Wales Hospital, Randwick, New South Wales, Australia sug: subj: Attention Deficit Hyperactivity Disorder Cerebral Cortex Drug Effects Cerebral Cortex Physiology Dopamine Agents Memory Disorders Norepinephrine Stress Disorders, Post-Traumatic Human ab: The aim of the present study was to review the dopamine theory of attention-deficit-hyperactivity disorder (ADHD), in light of recent use of noradrenergic therapies. A historical review of pharmacological theories of ADHD was conducted, including inverted-U, spatial working memory and neural circuit aspects. Pharmacological advances, including animal and human studies of dopaminergic and noradrenergic mechanisms at the prefrontal cortex (PFC), indicate that alpha-2A adrenoreceptor stimulation results in increased dendritic firing during delay periods for preferred directions, while moderate levels of D1 receptor stimulation result in reduction of delay-related firing to non-preferred directions, allowing representational control in the PFC. Recent studies of the COMT val/met gene and stimulant medication response may help explain variation in inverted-U responses in individuals. Further studies utilizing delay-related firing paradigms should be useful in the investigation of attentional syndromes, and responses to newer pharmacological treatments. pubtype: Academic Journal doctype: research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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