GABA-A receptor downregulation in brains of subjects with autism.
Gamma-aminobutyric acid A (GABAA) receptors are ligand-gated ion channels responsible for mediation of fast inhibitory action of GABA in the brain. Preliminary reports have demonstrated altered expression of GABA receptors in the brains of subjects with autism suggesting GABA/glutamate system dysreg...
| Publicado en: | Journal of Autism & Developmental Disorders Vol. 39; no. 2; pp. 223 - 231 |
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| Autores principales: | , , , |
| Formato: | pictorial research tables/charts Journal Article |
| Publicado: |
Springer Nature
Feb2009
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=105631333&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 105631333 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 01623257 AUT jtl: Journal of Autism & Developmental Disorders issn: 01623257 maglogo: N pubinfo: dt: Feb2009 vid: 39 iid: 2 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 105631333 105631333 2010171724 10.1007/s10803-008-0646-7 NLM18821008 105631333 ppf: 223 ppct: 8 formats: fmt: @attributes: type: P tig: atl: GABA-A receptor downregulation in brains of subjects with autism. aug: au: Fatemi SH Reutiman TJ Folsom TD Thuras PD affil: Department of Psychiatry, Division of Neuroscience Research, School of Medicine, University of Minnesota, 420 Delaware St SE, MMC 392 Minneapolis 55455 sug: subj: Autism Spectrum Disorder Physiopathology Brain Metabolism Brain Physiopathology GABA Receptors, Neurotransmitter Metabolism Adult Blotting, Western Brain Drug Effects Descriptive Statistics Experimental Studies Female Funding Source Male Matched Case Control Middle Age T-Tests Two-Tailed Test Human Adult: 19-44 years Middle Aged: 45-64 years Female Male ab: Gamma-aminobutyric acid A (GABAA) receptors are ligand-gated ion channels responsible for mediation of fast inhibitory action of GABA in the brain. Preliminary reports have demonstrated altered expression of GABA receptors in the brains of subjects with autism suggesting GABA/glutamate system dysregulation. We investigated the expression of four GABAA receptor subunitsand observed significant reductions in GABRA1, GABRA2, GABRA3, and GABRB3 in parietal cortex (Brodmann='s Area 40 (BA40)), while GABRA1 and GABRB3 were significantly altered in cerebellum, and GABRA1 was significantly altered in superior frontal cortex (BA9). The presence of seizure disorder did not have a significant impact on GABAA receptor subunit expression in the three brain areas. Our results demonstrate that GABAA receptors are reduced in three brain regions that have previously been implicated in the pathogenesis of autism, suggesting widespread GABAergic dysfunction in the brains of subjects with autism. pubtype: Academic Journal doctype: pictorial research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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