Periconceptional maternal vitamin supplementation and childhood leukaemia: an uncertainty analysis.
BACKGROUND: Recent studies in childhood cancer suggest that maternal vitamin supplementation may reduce the risk of leukaemia, neuroblastoma and certain types of childhood brain tumours. For example, a previous study found a significantly reduced risk of acute lymphoblastic leukaemia (ALL) but not a...
| Publicado en: | Journal of Epidemiology & Community Health Vol. 63; no. 2; pp. 168 - 173 |
|---|---|
| Autores principales: | , , , |
| Formato: | equations & formulas research tables/charts Journal Article |
| Publicado: |
BMJ Publishing Group
Feb2009
|
| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=105638121&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 105638121 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 0143005X C0H jtl: Journal of Epidemiology & Community Health issn: 0143005X maglogo: N pubinfo: dt: Feb2009 vid: 63 iid: 2 pid: 8280 pub: BMJ Publishing Group artinfo: ui: 105638121 105638121 2010178826 10.1136/jech.2008.080226 NLM18977808 105638121 ppf: 168 ppct: 5 formats: tig: atl: Periconceptional maternal vitamin supplementation and childhood leukaemia: an uncertainty analysis. aug: au: Jurek AM Maldonado G Spector LG Ross JA affil: University of Minnesota, Department of Pediatrics, Mayo Mail Code 715, 420 Delaware St. SE, Minneapolis, MN 55455, USA. jure0007@umn.edu sug: subj: Leukemia Prevention and Control Periconceptual Period Statistics Methods Vitamins Child Funding Source Odds Ratio Human Child: 6-12 years ab: BACKGROUND: Recent studies in childhood cancer suggest that maternal vitamin supplementation may reduce the risk of leukaemia, neuroblastoma and certain types of childhood brain tumours. For example, a previous study found a significantly reduced risk of acute lymphoblastic leukaemia (ALL) but not acute myeloid leukaemia (AML) in children with Down syndrome whose mothers reported any vitamin supplement use prior to knowledge of pregnancy (ALL OR adjusted for confounders 0.51, 95% confidence limits (CL): 0.30, 0.89; AML OR adjusted for confounders 0.92, 95% CL 0.48, 1.76). Recall of exposures, including maternal vitamin supplement use, however, may be difficult and subject to error. Epidemiologists are encouraged to quantitatively adjust for systematic error in study results, but often do not. METHODS: The impact that misclassification of maternal vitamin supplement use may have had on the observed ORs in this study was quantified. Uncertainty analysis was used to calculate ORs adjusted for inaccurate reporting of vitamin supplement use under assumed probability distributions for exposure misclassification parameters. RESULTS: Given our assumptions, adjustment for exposure misclassification yielded ORs that were predominantly more protective for ALL than the crude OR. CONCLUSIONS: Uncertainty analysis can give important insights into the magnitude and direction of error in study results due to exposure misclassification. pubtype: Academic Journal doctype: equations & formulas research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
|---|