Effects of exposure to 0.06 ppm ozone on FEV1 in humans: a secondary analysis of existing data.
BACKGROUND: Ozone is a potent photochemical oxidant that produces transient, reversible decrements in the lung function of acutely exposed individuals. A recent study provided previously unavailable clinical data for 30 healthy young adults exposed to O(3) at 0.06 ppm. That study showed significant...
| Publicado en: | Environmental Health Perspectives Vol. 116; no. 8; pp. 1023 - 1027 |
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| Autores principales: | , , |
| Formato: | research Journal Article |
| Publicado: |
National Institute of Environmental Health Sciences
Aug2008
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=105649215&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 105649215 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 00916765 3B5 jtl: Environmental Health Perspectives issn: 00916765 maglogo: N pubinfo: dt: Aug2008 vid: 116 iid: 8 pid: 56539 pub: National Institute of Environmental Health Sciences place: Research Triangle Park, North Carolina artinfo: ui: 105649215 105649215 2010003038 10.1289/ehp.11396 NLM18709151 105649215 ppf: 1023 ppct: 4 formats: fmt: @attributes: type: P tig: atl: Effects of exposure to 0.06 ppm ozone on FEV1 in humans: a secondary analysis of existing data. aug: au: Brown JS Bateson TF McDonnell WF affil: US Environmental Protection Agency, Office of Research and Development, National Center for Environmental Assessment, B243-01, Research Triangle Park, NC 27711 USA; Brown.James@epa.gov sug: subj: Air Pollutants Environmental Exposure Forced Expiratory Volume Drug Effects Ozone Adult Female Funding Source Male Human Adult: 19-44 years Female Male ab: BACKGROUND: Ozone is a potent photochemical oxidant that produces transient, reversible decrements in the lung function of acutely exposed individuals. A recent study provided previously unavailable clinical data for 30 healthy young adults exposed to O(3) at 0.06 ppm. That study showed significant effects of 0.08 ppm on lung function, confirming the findings of others. However, exposure to 0.06 ppm O(3) was not reported to significantly affect lung function. OBJECTIVES: We conducted this analysis to reevaluate the existing lung function data of the volunteers previously exposed to 0.06 ppm O(3). METHODS: We obtained pre- and postexposure data on forced expiratory volume in 1 sec (FEV(1)) for all subjects who were previously exposed for 6.6 hr to filtered air or to 0.06 ppm or 0.08 ppm O(3). We used standard statistical methods appropriate for paired comparisons to reanalyze FEV(1) responses after exposure to 0.06 ppm O(3) relative to filtered air. RESULTS: Controlling for filtered air responses, 24 of the 30 subjects experienced an O(3)-induced decrement in FEV(1). On average, 0.06 ppm O(3) exposure caused a 2.85% reduction in FEV(1) (p < 0.002), which was consistent with the predicted FEV(1) response from existing models. Although the average response was small, two subjects had > 10% FEV(1) decrements. CONCLUSIONS: Exposure to 0.06 ppm O(3) causes a biologically small but highly statistically significant decrease in mean FEV(1) responses of young healthy adults. pubtype: Academic Journal doctype: research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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