Plasminogen activator inhibitor type 1 is the most significant of the usual tissue prognostic factors in node-negative breast ductal adenocarcinoma independent of urokinase-type plasminogen activator.
PURPOSE: The aim of the present investigation was to evaluate the prognostic significance of urokinase-type plasminogen activator (uPA) and plasminogen activator inhibitor-1 (PAI-1) tissue contents in primary breast adenocarcinoma. PATIENTS AND METHODS: Patients from 3 medical centers were included...
| Publicado en: | Clinical Breast Cancer Vol. 8; no. 2; pp. 168 - 178 |
|---|---|
| Autores principales: | , , , , , , , |
| Formato: | algorithm research tables/charts Journal Article |
| Publicado: |
Elsevier B.V.
2008 Apr
|
| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=105650658&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 105650658 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 15268209 G4D jtl: Clinical Breast Cancer issn: 15268209 maglogo: N pubinfo: dt: 2008 Apr vid: 8 iid: 2 pid: 467 pub: Elsevier B.V. place: New York, New York artinfo: ui: 105650658 105650658 2009994582 NLM18621614 105650658 ppf: 168 ppct: 10 formats: tig: atl: Plasminogen activator inhibitor type 1 is the most significant of the usual tissue prognostic factors in node-negative breast ductal adenocarcinoma independent of urokinase-type plasminogen activator. aug: au: Descotes F Riche B Saez S De Laroche G Datchary J Roy P André J Bobin JY affil: Service de Biologie des Tumeurs Solides, Centre Hospitalier Universitaire Lyon-Sud, Pierre Benite, France. francoise.descotes@chu-lyon.fr sug: subj: Carcinoma, Ductal, Breast Prognosis Plasminogen Activators Antagonists and Inhibitors Algorithms Carcinoma, Ductal, Breast Classification Chemotherapy, Cancer Confidence Intervals Cox Proportional Hazards Model Demography Descriptive Statistics France Kaplan-Meier Estimator Log-Rank Test Multivariate Analysis Univariate Statistics Human ab: PURPOSE: The aim of the present investigation was to evaluate the prognostic significance of urokinase-type plasminogen activator (uPA) and plasminogen activator inhibitor-1 (PAI-1) tissue contents in primary breast adenocarcinoma. PATIENTS AND METHODS: Patients from 3 medical centers were included between 1994 and 2001. Biologic factors in tumor extracts were all assayed in the same laboratory. PAI-1 and uPA were treated as continuous or dichotomized variables. Metastasis-free survival analyses were performed using the Cox model and the classification algorithm and regression tree (CART) in the whole population and in the subsets of node-negative (pN0) or positive (pN+) cases. Kaplan curves of metastasis-free survival were designed for different groups in relation to uPA/PAI-1 combinations. Urokinase-type plasminogen activator tumor level appears related to the anatomic degree of extension; conversely, PAI-1 tumor content is independent of tumor size and nodal extension. RESULTS: In univariate analysis, adjusted on usual prognostic factors, the metastasis risk increased with PAI-1 level in all patients (HR [hazard ratio], 3.1; P < .001), in pN0 (HR, 4.3; P < .001), and pN+ patients (HR, 2.3; P = .019). It increased also with uPA in all patients (HR, 2.6; P = 0.006). In multivariate analysis, when both variables were included, PAI-1 remained significant in all patients (HR, 2.4; P = .002) and pN0 patients (HR, 3.2; P = .003) but not uPA. CART analyses confirmed that the best partitioning factor was PAI-1. CONCLUSION: There was no evidence for any additional impact of uPA. PAI-1 is an independent prognostic factor in particular in pN0 breast ductal carcinoma. pubtype: Academic Journal doctype: algorithm research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
|---|