Diesel exhaust inhalation elicits acute vasoconstriction in vivo.
BACKGROUND: Traffic-related air pollution is consistently associated with cardiovascular morbidity and mortality. Recent human and animal studies suggest that exposure to air pollutants affects vascular function. Diesel exhaust (DE) is a major source of traffic-related air pollution. OBJECTIVES: Our...
| Publicado en: | Environmental Health Perspectives Vol. 116; no. 7; pp. 937 - 943 |
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| Autores principales: | , , , , , , , , , |
| Formato: | clinical trial research Journal Article |
| Publicado: |
National Institute of Environmental Health Sciences
Jul2008
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=105654683&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 105654683 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 00916765 3B5 jtl: Environmental Health Perspectives issn: 00916765 maglogo: N pubinfo: dt: Jul2008 vid: 116 iid: 7 pid: 56539 pub: National Institute of Environmental Health Sciences place: Research Triangle Park, North Carolina artinfo: ui: 105654683 105654683 2009966732 10.1289/ehp.11027 NLM18629317 105654683 ppf: 937 ppct: 6 formats: fmt: @attributes: type: P tig: atl: Diesel exhaust inhalation elicits acute vasoconstriction in vivo. aug: au: Peretz A Sullivan JH Leotta DF Trenga CA Sands FN Allen J Carlsten C Wilkinson CW Gill EA Kaufman JD affil: Occupational and Environmental Medicine Program, Department of Environmental and Occupational Health Sciences, University of Washington, Seattle, Washington, USA sug: subj: Air Pollution Brachial Artery Drug Effects Environmental Exposure Adverse Effects Metabolic Syndrome X Physiopathology Particulate Matter Vasoconstriction Drug Effects Adult Brachial Artery Physiopathology Brachial Artery Ultrasonography Catecholamines Metabolism Crossover Design Dose-Response Relationship, Drug Double-Blind Studies Endothelins Metabolism Female Male Metabolic Syndrome X Metabolism Middle Age Time Factors Vasodilation Drug Effects Human Adult: 19-44 years Middle Aged: 45-64 years Female Male ab: BACKGROUND: Traffic-related air pollution is consistently associated with cardiovascular morbidity and mortality. Recent human and animal studies suggest that exposure to air pollutants affects vascular function. Diesel exhaust (DE) is a major source of traffic-related air pollution. OBJECTIVES: Our goal was to study the effects of short-term exposure to DE on vascular reactivity and on mediators of vascular tone. METHODS: In a double-blind, crossover, controlled exposure study, 27 adult volunteers (10 healthy and 17 with metabolic syndrome) were exposed in randomized order to filtered air (FA) and each of two levels of diluted DE (100 or 200 microg/m(3) of fine particulate matter) in 2-hr sessions. Before and after each exposure, we assessed the brachial artery diameter (BAd) by B-mode ultrasound and collected blood samples for endothelin-1 (ET-1) and catecholamines. Postexposure we also assessed endothelium-dependent flow-mediated dilation (FMD). RESULTS: Compared with FA, DE at 200 microg/m(3) elicited a decrease in BAd (0.11 mm; 95% confidence interval, 0.02-0.18), and the effect appeared linearly dose related with a smaller effect at 100 microg/m(3). Plasma levels of ET-1 increased after 200 microg/m(3) DE but not after FA (p = 0.01). There was no consistent impact of DE on plasma catecholamines or FMD. CONCLUSIONS: These results demonstrate that short-term exposure to DE is associated with acute endothelial response and vasoconstriction of a conductance artery. Elucidation of the signaling pathways controlling vascular tone that underlie this observation requires further study. pubtype: Academic Journal doctype: clinical trial research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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