How many subjects are necessary for population pharmacokinetic experiments? Confidence interval approach.
OBJECTIVE: To describe an approach using simulations for determining sample size for population pharmacokinetic experiments METHODS: We address this problem by proposing method based on the estimation of the model parameters. The power to estimate the confidence interval of a parameter of choice to...
| Publicado en: | European Journal of Clinical Pharmacology Vol. 64; no. 7; pp. 705 - 714 |
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| Autores principales: | , |
| Formato: | equations & formulas research tables/charts Journal Article |
| Publicado: |
Springer Nature
Jul2008
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| Acceso en línea: | Ver este registro en EBSCOhost |