Incentive-elicited striatal activation in adolescent children of alcoholics.
AIMS: Deficient recruitment of motivational circuitry by non-drug rewards has been postulated as a pre-morbid risk factor for substance dependence (SD). We tested whether parental alcoholism, which confers risk of SD, is correlated with altered recruitment of ventral striatum (VS) by non-drug reward...
| Publicado en: | Addiction Vol. 103; no. 8; pp. 1308 - 1320 |
|---|---|
| Autores principales: | , , |
| Formato: | diagnostic images research tables/charts Journal Article |
| Publicado: |
Wiley-Blackwell
Aug2008
|
| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=105674543&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 105674543 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 09652140 AIO jtl: Addiction issn: 09652140 maglogo: Y pubinfo: dt: Aug2008 vid: 103 iid: 8 pid: 480 pub: Wiley-Blackwell place: Malden, Massachusetts artinfo: ui: 105674543 2010037490 10.1111/j.1360-0443.2008.02250.x NLM18851716 105674543 ppf: 1308 ppct: 12 formats: fmt: @attributes: type: P tig: atl: Incentive-elicited striatal activation in adolescent children of alcoholics. aug: au: Bjork JM Knutson B Hommer DW affil: Laboratory of Clinical and Translational Studies, National Institute on Alcohol Abuse and Alcoholism, NIH, Bethesda, MD, USA sug: subj: Alcoholism Risk Factors Basal Ganglia Physiology Children of Persons with Alcoholism Motivation Reward Adolescence Analysis of Variance Checklists Child Child Behavior Checklist Cues Descriptive Statistics Female Funding Source Interview Guides Interviews Magnetic Resonance Imaging Male Matched Case Control Multiple Regression Oxygen Blood Psychological Tests Reaction Time Scales Self Report T-Tests Time Series Human Adolescent: 13-18 years Child: 6-12 years Female Male ab: AIMS: Deficient recruitment of motivational circuitry by non-drug rewards has been postulated as a pre-morbid risk factor for substance dependence (SD). We tested whether parental alcoholism, which confers risk of SD, is correlated with altered recruitment of ventral striatum (VS) by non-drug rewards in adolescence. DESIGN: During functional magnetic resonance imaging, adolescent children of alcoholics (COA; age 12-16 years) with no psychiatric disorders (including substance abuse) and similarly aged children with no risk factors responded to targets to win or avoid losing $0, $0.20, $1, $5 or a variable amount (ranging from $0.20 to $5). RESULTS: In general, brain activation by either reward anticipation or outcome notification did not differ between COA and age/gender-matched controls. Cue-elicited reward anticipation activated portions of VS in both COA and controls. In nucleus accumbens (NAcc), signal change increased with anticipated reward magnitude (with intermediate recruitment by variable incentives) but not with loss magnitudes. Reward deliveries activated the NAcc and mesofrontal cortex in both COA and controls. Losses activated anterior insula bilaterally in both groups, with more extensive right anterior insula activation by losses in controls. NAcc signal change during anticipation of maximum rewards (relative to non-reward) correlated positively with both Brief Sensation-Seeking Scale scores and with self-reported excitement in response to maximum reward cues (relative to cues for non-reward). CONCLUSIONS: Among adolescents with no psychiatric disorders, incentive-elicited VS activation may relate more to individual differences in sensation-seeking personality than to presence of parental alcoholism alone. Future research could focus on adolescents with behavior disorders or additional risk factors. pubtype: Academic Journal doctype: diagnostic images research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
|---|