Cryptococcus neoformans strains and infection in apparently immunocompetent patients, China.
To determine the population structure of the cryptococcosis agents in China, we analyzed the genotype of 120 Cryptococcus neoformans and 9 Cryptococcus gattii strains isolated from 1980 through 2006 from cryptococcosis patients residing in 16 provinces of mainland China. A total of 71% (91/129) of t...
| Publicado en: | Emerging Infectious Diseases Vol. 14; no. 5; pp. 755 - 763 |
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| Autores principales: | , , , , , , , , , , , |
| Formato: | Journal Article |
| Publicado: |
Centers for Disease Control & Prevention (CDC)
May2008
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=105679576&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 105679576 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 10806040 EFD jtl: Emerging Infectious Diseases issn: 10806040 maglogo: N pubinfo: dt: May2008 vid: 14 iid: 5 pid: 1493 pub: Centers for Disease Control & Prevention (CDC) place: Atlanta, Georgia artinfo: ui: 105679576 105679576 NLM18439357 2010067846 10.3201/eid1405.071312 NLM18439357 PMC2600263 105679576 ppf: 755 ppct: 8 formats: tig: atl: Cryptococcus neoformans strains and infection in apparently immunocompetent patients, China. aug: au: Chen J Varma A Diaz MR Litvintseva AP Wollenberg KK Kwon-Chung KJ Chen, Jianghan Varma, Ashok Diaz, Mara R Litvintseva, Anastasia P Wollenberg, Kurt K Kwon-Chung, Kyung J affil: Shanghai Changzheng Hospital, Shanghai, People's Republic of China sug: subj: Cryptococcosis Epidemiology Cryptococcosis Microbiology Cryptococcosis Physiopathology Cryptococcus Classification Cryptococcus Immunocompetence AIDS-Related Opportunistic Infections Epidemiology AIDS-Related Opportunistic Infections Microbiology Animals Bacterial Typing Techniques China Female Genotype Male Mice Polymorphism, Genetic Proteins Sequence Analysis Virulence Female Male ab: To determine the population structure of the cryptococcosis agents in China, we analyzed the genotype of 120 Cryptococcus neoformans and 9 Cryptococcus gattii strains isolated from 1980 through 2006 from cryptococcosis patients residing in 16 provinces of mainland China. A total of 71% (91/129) of the clinical strains isolated from 1985 through 2006 were from patients without any apparent risk factors. Only 8.5% (11/129) were from AIDS patients; the remaining 20.5% (27/129) were from patients with underlying diseases other than HIV infection. One hundred twenty of the 129 isolates were C. neoformans serotype A, mating type MATalpha strains that exhibited an identical M13-based VNI subtype, which was distinguishable from the reference VNI molecular type. The 9 remaining isolates were serotype B, MATalpha strains of C. gattii and portrayed a typical VGI molecular type. Data analyzed from multilocus sequences showed no variation and that these Chinese C. neoformans isolates belong to a cluster that has phylogenetically diverged from the VNI reference strain. Our finding that most cryptococcosis patients in China had no apparent risk factor is in stark contrast with reports from other countries. pubtype: Academic Journal doctype: Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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