Differentiating normal hyaline cartilage from post-surgical repair tissue using fast gradient echo imaging in delayed gadolinium-enhanced MRI (dGEMRIC) at 3 Tesla.
The purpose was to evaluate the relative glycosaminoglycan (GAG) content of repair tissue in patients after microfracturing (MFX) and matrix-associated autologous chondrocyte transplantation (MACT) of the knee joint with a dGEMRIC technique based on a newly developed short 3D-GRE sequence with two f...
| Publicado en: | European Radiology Vol. 18; no. 6; pp. 1251 - 1260 |
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| Autores principales: | , , , , , , , , , , , , , , , |
| Formato: | research Journal Article |
| Publicado: |
Springer Nature
Jun2008
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=105684434&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 105684434 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 09387994 NPH jtl: European Radiology issn: 09387994 maglogo: N pubinfo: dt: Jun2008 vid: 18 iid: 6 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 105684434 31910433 NLM18246356 2009917524 10.1007/s00330-008-0859-3 NLM18246356 105684434 ppf: 1251 ppct: 9 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Differentiating normal hyaline cartilage from post-surgical repair tissue using fast gradient echo imaging in delayed gadolinium-enhanced MRI (dGEMRIC) at 3 Tesla. aug: au: Trattnig S Mamisch TC Pinker K Domayer S Szomolanyi P Marlovits S Kutscha-Lissberg F Welsch GH Trattnig, Siegfried Mamisch, Tallal C Pinker, Katja Domayer, Stephan Szomolanyi, Pavol Marlovits, Stefan Kutscha-Lissberg, Florian Welsch, Goetz H affil: MR Center-High field MR, Department of Radiology, Medical University of Vienna, Lazarettgasse 14, A-1090 Vienna, Austria sug: subj: Cartilage Metabolism Connective Tissue Cells Transplantation Glycosaminoglycans Metabolism Knee Joint Surgery Magnetic Resonance Imaging Methods Adult Aged Analysis of Variance Autografts Cartilage Pathology Cell Transplantation Methods Connective Tissue Cells Metabolism Contrast Media Diagnostic Use Contrast Media Diagnostic Imaging Female Image Processing, Computer Assisted Male Middle Age Phantoms, Imaging Sodium Chloride Diagnostic Use Tissue Culture Techniques Wound Healing Human Adult: 19-44 years Aged: 65+ years Middle Aged: 45-64 years Female Male ab: The purpose was to evaluate the relative glycosaminoglycan (GAG) content of repair tissue in patients after microfracturing (MFX) and matrix-associated autologous chondrocyte transplantation (MACT) of the knee joint with a dGEMRIC technique based on a newly developed short 3D-GRE sequence with two flip angle excitation pulses. Twenty patients treated with MFX or MACT (ten in each group) were enrolled. For comparability, patients from each group were matched by age (MFX: 37.1 +/- 16.3 years; MACT: 37.4 +/- 8.2 years) and postoperative interval (MFX: 33.0 +/- 17.3 months; MACT: 32.0 +/- 17.2 months). The Delta relaxation rate (DeltaR1) for repair tissue and normal hyaline cartilage and the relative DeltaR1 were calculated, and mean values were compared between both groups using an analysis of variance. The mean DeltaR1 for MFX was 1.07 +/- 0.34 versus 0.32 +/- 0.20 at the intact control site, and for MACT, 1.90 +/- 0.49 compared to 0.87 +/- 0.44, which resulted in a relative DeltaR1 of 3.39 for MFX and 2.18 for MACT. The difference between the cartilage repair groups was statistically significant. The new dGEMRIC technique based on dual flip angle excitation pulses showed higher GAG content in patients after MACT compared to MFX at the same postoperative interval and allowed reducing the data acquisition time to 4 min. pubtype: Academic Journal doctype: research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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