GUDMAP: the genitourinary developmental molecular anatomy project.
In late 2004, an International Consortium of research groups were charged with the task of producing a high-quality molecular anatomy of the developing mammalian urogenital tract (UGT). Given the importance of these organ systems for human health and reproduction, the need for a systematic molecular...
| Publicado en: | Journal of the American Society of Nephrology (JASN) Vol. 19; no. 4; pp. 667 - 672 |
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| Autores principales: | , , , , , , , , , , , , , , , , , , , |
| Formato: | Journal Article |
| Publicado: |
Lippincott Williams & Wilkins
Apr2008
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=105691920&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 105691920 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 10466673 1X25 jtl: Journal of the American Society of Nephrology (JASN) issn: 10466673 maglogo: N pubinfo: dt: Apr2008 vid: 19 iid: 4 pid: 433 pub: Lippincott Williams & Wilkins place: Baltimore, Maryland artinfo: ui: 105691920 NLM18287559 2010087175 10.1681/ASN.2007101078 NLM18287559 105691920 ppf: 667 ppct: 5 formats: tig: atl: GUDMAP: the genitourinary developmental molecular anatomy project. aug: au: McMahon AP Aronow BJ Davidson DR Davies JA Gaido KW Grimmond S Lessard JL Little MH Potter SS Wilder EL Zhang P McMahon, Andrew P Aronow, Bruce J Davidson, Duncan R Davies, Jamie A Gaido, Kevin W Grimmond, Sean Lessard, James L Little, Melissa H Potter, S Steven affil: Department of Molecular and Cellular Biology and Harvard Stem Cell Institute, Harvard University, 16, Divinity Avenue, Cambridge, MA 02138, USA sug: subj: Urogenital System Anatomy and Histology Urogenital System Animals Mice Molecular Biology Resource Databases ab: In late 2004, an International Consortium of research groups were charged with the task of producing a high-quality molecular anatomy of the developing mammalian urogenital tract (UGT). Given the importance of these organ systems for human health and reproduction, the need for a systematic molecular and cellular description of their developmental programs was deemed a high priority. The information obtained through this initiative is anticipated to enable the highest level of basic and clinical research grounded on a 21st-century view of the developing anatomy. There are three components to the Genitourinary Developmental Molecular Anatomy Project GUDMAP; all of these are intended to provide resources that support research on the kidney and UGT. The first provides ontology of the cell types during UGT development and the molecular hallmarks of those cells as discerned by a variety of procedures, including in situ hybridization, transcriptional profiling, and immunostaining. The second generates novel mouse strains. In these strains, cell types of particular interest within an organ are labeled through the introduction of a specific marker into the context of a gene that exhibits appropriate cell type or structure-specific expression. In addition, the targeting construct enables genetic manipulation within the cell of interest in many of the strains. Finally, the information is annotated, collated, and promptly released at regular intervals, before publication, through a database that is accessed through a Web portal. Presented here is a brief overview of the Genitourinary Developmental Molecular Anatomy Project effort. pubtype: Academic Journal doctype: Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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