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Sarcoidosis as risk factor for cryptococcal meningitis in an apparently immunocompetent patient.

Cryptoccus neoformans meningitis (CNM) is an opportunistic infection that typically occurs in immunosuppressed patients. Subjects affected by sarcoidosis, a systemic granulomatous disease of unknown cause, are predisposed to CNM because of the impairment of cell-mediated immunity and because of the...

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Publicado en:Neurological Sciences Vol. 29; no. 1; pp. 33 - 36
Autores principales: Cancelli I, Merlino G, Serafini A, Valente M, Gigli GL, Cancelli, Iacopo, Merlino, Giovanni, Serafini, Anna, Valente, Mariarosaria, Gigli, Gian Luigi
Formato: case study Journal Article
Publicado: Springer Nature Feb2008
Acceso en línea:Ver este registro en EBSCOhost
Sumario:Cryptoccus neoformans meningitis (CNM) is an opportunistic infection that typically occurs in immunosuppressed patients. Subjects affected by sarcoidosis, a systemic granulomatous disease of unknown cause, are predisposed to CNM because of the impairment of cell-mediated immunity and because of the chronic corticosteroid therapy they frequently receive. Here we report the case of a 38-year-old man who developed CNM as the first clinical manifestation of sarcoidosis. The patient developed CNM even though he was apparently immunocompetent and was not on therapy with either corticosteroid or cytotoxic drugs.