Embryonic conduction tissue: a spatial correlation with adult arrhythmogenic areas.
CCS-lacZ Expression in Conduction System Development. Introduction: The occurrence of arrhythmias in adult patients may arise preferentially in anatomic regions derived from the specialized cardiac conduction system. To examine this hypothesis, we performed a detailed analysis of the developing card...
| Publicado en: | Journal of Cardiovascular Electrophysiology Vol. 15; no. 3; pp. 349 - 356 |
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| Autores principales: | , , , , , , , |
| Formato: | Journal Article |
| Publicado: |
Wiley-Blackwell
Mar2004
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=105716428&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 105716428 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 10453873 GSB jtl: Journal of Cardiovascular Electrophysiology issn: 10453873 maglogo: Y pubinfo: dt: Mar2004 vid: 15 iid: 3 pid: 480 pub: Wiley-Blackwell place: Malden, Massachusetts artinfo: ui: 105716428 105716428 2009393839 10.1046/j.1540-8167.2004.03487.x NLM15030427 105716428 ppf: 349 ppct: 7 formats: fmt: @attributes: type: P tig: atl: Embryonic conduction tissue: a spatial correlation with adult arrhythmogenic areas. aug: au: Jongbloed MR Schalij MJ Poelmann RE Blom NA Fekkes ML Wang Z Fishman GI Gittenberger-De Groot AC sug: subj: Arrhythmia Embryology Heart Conduction System Embryology Heart Conduction System Animals Arrhythmia Metabolism Arrhythmia Physiopathology Fetal Heart Embryology Fetal Heart Physiology Fetal Heart Genome Gestational Age Glycoside Hydrolases Heart Atrium Embryology Heart Atrium Heart Conduction System Metabolism Heart Ventricle Embryology Heart Ventricle Metabolism Heart Ventricle Mice Physiology Models, Biological Myocardium Reproduction Statistics ab: CCS-lacZ Expression in Conduction System Development. Introduction: The occurrence of arrhythmias in adult patients may arise preferentially in anatomic regions derived from the specialized cardiac conduction system. To examine this hypothesis, we performed a detailed analysis of the developing cardiac conduction system using the recently described CCS-lacZ transgenic mouse strain. Methods and Results: Transgenic embryos (E9.5-15.5) were stained for [beta]-galactosidase activity and co-stained with the myocardial marker HHF35. Results were reconstructed three dimensionally. CCS-lacZ expression was observed in the sinoatrial node, left and right venous valves, septum spurium, right and left atrioventricular ring, His bundle, bundle branches, and right ventricular moderator band. Furthermore, lacZ-positive cells could be demonstrated for the first time in the left atrium, in the posterior wall surrounding the pulmonary venous orifice. and, in later stages, surrounding the pulmonary venous wall. These cells were continuous with the left venous valve in the right atrium. LacZ-positive tissue also could be identified in Bachmann's bundle, running retro-aortically between the right atrium and left atrium. Conclusion: Known arrhythmogenic areas including Bachmann's bundle, the pulmonary veins, and sinus venosus derived internodal structures, demonstrate lacZ expression. These data support the hypothesis that areas derived from the developing cardiac conduction system may contribute to the arrhythmogenic substrate in adult hearts. (J Cardiovasc Electrophysiol, Vol. 15, pp. 349-355, March 2004) pubtype: Academic Journal doctype: Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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