Effects of Spatial Segmentation in the Continuous Model of Excitation Propagation in Cardiac Muscle.
Introduction: Spatial segmentation is essential for the numerical simulation of excitation propagation in cardiac muscle. Methods and Results: This study evaluated the effects of spatial segmentation on action potential and on the velocity of propagation in a continuous one-dimensional model of card...
| Publicado en: | Journal of Cardiovascular Electrophysiology Vol. 10; no. 7; pp. 965 - 973 |
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| Autores principales: | , |
| Formato: | research Journal Article |
| Publicado: |
Wiley-Blackwell
Jul1999
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=105716715&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 105716715 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 10453873 GSB jtl: Journal of Cardiovascular Electrophysiology issn: 10453873 maglogo: Y pubinfo: dt: Jul1999 vid: 10 iid: 7 pid: 480 pub: Wiley-Blackwell place: Malden, Massachusetts artinfo: ui: 105716715 105716715 2009405054 NLM10413376 105716715 ppf: 965 ppct: 8 formats: fmt: @attributes: type: P tig: atl: Effects of Spatial Segmentation in the Continuous Model of Excitation Propagation in Cardiac Muscle. aug: au: Wu J Zipes DP sug: subj: Action Potentials Physiology Computer Simulation Heart Physiology Myocardial Contraction Physiology Myocardium Reproducibility of Results Human ab: Introduction: Spatial segmentation is essential for the numerical simulation of excitation propagation in cardiac muscle. Methods and Results: This study evaluated the effects of spatial segmentation on action potential and on the velocity of propagation in a continuous one-dimensional model of cardiac muscle [intracellular and extracellular resistivities along (L) and transverse (T) to the muscle fibers: 402 cm (Ri, L), 3,620 cm (Ri, T), 48 cm (Re, L), and 126 cm (Re, T), J of Physiol 255:335-346, 1976) and either Luo-Rudy (L-R, Circ Res 68:1501-1526, 1991) or Beeler-Reuter (B-R, J Physiol 268:177-210, 1977) ionic currents. Related cable equations for active membrane are derived. Spatial segmentations of < 31.2 um (L, L-R), < 11.5 um (T, L-R), < ;44.7 um (L, B-R), and < 16.5 um (T, B-R) were required for < 1 % errors in the characteristic parameters of action potential. Similarly, spatial segmentations of < 54.5 um (L, L-R), <20.1 um (T, L-R), <84.3 um (L, B-R), and <31.2 um (T, B-R) were required for <1% errors in the velocity of conduction. Conclusion: In general, spatial segmentations of < 26.9% and <50.8% of the space constant of a fully activated membrane gave < 1.0% errors in the characteristic parameters of action potential and in the velocity of propagation, respectively, for both membranes. The action potential duration was relatively insensitive to the spatial segmentation. Our analysis suggests that [lamda]full is a better criterion for the selection of spatial segmentation in numerical simulation than the space constant of the resting membrane. pubtype: Academic Journal doctype: research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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