Two nomograms for determining extended-dosing intervals for gentamicin in neonates.
PURPOSE: The development of two nomograms to predict dosing intervals for gentamicin in neonates based on one gentamicin concentration is described. METHODS: Pooled data from three retrospective studies on neonates age seven days or younger were used to create nomograms that would predict dosing int...
| Publicado en: | American Journal of Health-System Pharmacy Vol. 65; no. 7; pp. 624 - 631 |
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| Autores principales: | , |
| Formato: | research Journal Article |
| Publicado: |
Oxford University Press / USA
4/1/2008
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=105719677&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 105719677 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 10792082 1X3 jtl: American Journal of Health-System Pharmacy issn: 10792082 maglogo: N pubinfo: dt: 4/1/2008 vid: 65 iid: 7 pid: 622 pub: Oxford University Press / USA artinfo: ui: 105719677 2009885192 10.2146/ajhp070314 NLM18359969 105719677 ppf: 624 ppct: 7 formats: fmt: @attributes: type: P tig: atl: Two nomograms for determining extended-dosing intervals for gentamicin in neonates. aug: au: Murphy JE Roether AM affil: College of Pharmacy, University of Arizona, Tucson, AZ 85721-0202, USA. murphy@pharmacy.arizona.edu <murphy@pharmacy.arizona.edu> sug: subj: Antibiotics Administration and Dosage Antibiotics Blood Gentamicins Administration and Dosage Gentamicins Blood Antibiotics Pharmacokinetics Dosage Forms Dose-Response Relationship, Drug Drug Administration Schedule Gentamicins Pharmacokinetics Infant, Newborn Models, Statistical Time Human Infant, Newborn: birth-1 month ab: PURPOSE: The development of two nomograms to predict dosing intervals for gentamicin in neonates based on one gentamicin concentration is described. METHODS: Pooled data from three retrospective studies on neonates age seven days or younger were used to create nomograms that would predict dosing intervals for gentamicin. The population volume of distribution (0.45 L/kg) and a determined half-life were used to create nomogram cutoff concentrations that could select a dosing interval for neonates to achieve steady-state trough concentrations of < or =0.5 or < or =1 mg/L. A dose of 4 mg/kg was used to simulate concentration-versus-time profiles for included neonates based on their individual pharmacokinetic data. Predicted concentrations from hours 6 to 22, at one-hour intervals, for each neonate were compared against the nomograms and evaluated for the number of correct interval predictions. The nomograms were considered to have failed at any time point where they indicated an interval that would not have achieved the desired trough concentration of < or =0.5 or < or =1 mg/L or if the interval chosen was longer than necessary. RESULTS: The 0.5- and 1-mg/L nomograms predicted correct dosing intervals for 81-92% of neonates for postinfusion hours between 15 to 21 and 86-93% for postinfusion hours of 13 and 21, respectively. Accuracy of the nomograms to predict correct dosing intervals improved as the postinfusion time before the next concentration measurement increased. CONCLUSION: Using the two nomograms may help predict the correct extended-dosing intervals of gentamicin administration for neonates. Prospective evaluation and validation of the nomograms may be necessary for their wider use as a clinical tool. pubtype: Academic Journal doctype: research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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