Effect of sildenafil citrate (viagra) on coronary flow in normal subjects.
Background: The purpose of this study was to evaluate the effect of sildenafil citrate (Viagra) on coronary function in normal subjects. Methods: The study assessed mean blood pressure, left anterior descending coronary artery (LAD) flow, and echocardiographic variables before and 30 and 60 minutes...
| Publicado en: | Echocardiography Vol. 25; no. 1; pp. 72 - 77 |
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| Autores principales: | , , , , |
| Formato: | research Journal Article |
| Publicado: |
Wiley-Blackwell
Jan2008
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=105725407&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 105725407 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 07422822 GSE jtl: Echocardiography issn: 07422822 maglogo: Y pubinfo: dt: Jan2008 vid: 25 iid: 1 pid: 480 pub: Wiley-Blackwell place: Malden, Massachusetts artinfo: ui: 105725407 105725407 2009760713 10.1111/j.1540-8175.2007.00557.x NLM18186782 105725407 ppf: 72 ppct: 5 formats: fmt: @attributes: type: P tig: atl: Effect of sildenafil citrate (viagra) on coronary flow in normal subjects. aug: au: Ishikura F Beppu S Ueda H Nehra A Khandheria BK affil: School of Allied Health Sciences, Osaka University, Faculty of Medicine, Osaka, Japan. sug: subj: Coronary Circulation Drug Effects Heterocyclic Compounds Pharmacodynamics Sulfur Compounds Pharmacodynamics Vasodilator Agents Pharmacodynamics Adult Blood Flow Velocity Drug Effects Blood Pressure Drug Effects Echocardiography, Doppler Heart Rate Drug Effects Male Purines Pharmacodynamics Human Adult: 19-44 years Male ab: Background: The purpose of this study was to evaluate the effect of sildenafil citrate (Viagra) on coronary function in normal subjects. Methods: The study assessed mean blood pressure, left anterior descending coronary artery (LAD) flow, and echocardiographic variables before and 30 and 60 minutes after taking 50 mg of sildenafil citrate. The mean velocity of LAD flow was assessed with Doppler flow imaging. The study subjects were 6 healthy male volunteers (mean age 37 years). Results: The mean velocity of LAD flow increased 60 minutes after taking sildenafil citrate, but there were no other changes. Two volunteers felt mild flashing and one had mild headache during the study. Conclusion: Sildenafil citrate caused vasodilatation in a normal coronary artery without systemic pressure drops. These results suggest that the agent itself did not have negative effects on the heart in normal subjects. pubtype: Academic Journal doctype: research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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