Effect of inhaled carbon ultrafine particles on reactive hyperemia in healthy human subjects.
BACKGROUND: Ultrafine particles (UFP) may contribute to the cardiovascular effects of exposure to particulate air pollution, partly because of their relatively efficient alveolar deposition and potential to enter the pulmonary vascular space. OBJECTIVES: This study tested the hypothesis that inhalat...
| Publicado en: | Environmental Health Perspectives Vol. 116; no. 3; pp. 375 - 381 |
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| Autores principales: | , , , , , , , , |
| Formato: | Journal Article |
| Publicado: |
National Institute of Environmental Health Sciences
Mar2008
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=105725450&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 105725450 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 00916765 3B5 jtl: Environmental Health Perspectives issn: 00916765 maglogo: N pubinfo: dt: Mar2008 vid: 116 iid: 3 pid: 56539 pub: National Institute of Environmental Health Sciences place: Research Triangle Park, North Carolina artinfo: ui: 105725450 105725450 2009863201 10.1289/ehp.10323 NLM18335106 105725450 ppf: 375 ppct: 6 formats: fmt: @attributes: type: P tig: atl: Effect of inhaled carbon ultrafine particles on reactive hyperemia in healthy human subjects. aug: au: Shah AP Pietropaoli AP Frasier LM Speers DM Chalupa DC Delehanty JM Huang LS Utell MJ Frampton MW sug: subj: Air Pollutants Carbon Environmental Exposure Adverse Effects Hyperemia Chemically Induced Particulate Matter Adolescence Adult Exercise Female Forearm Blood Supply Hemodynamics Male Time Factors Adolescent: 13-18 years Adult: 19-44 years Female Male ab: BACKGROUND: Ultrafine particles (UFP) may contribute to the cardiovascular effects of exposure to particulate air pollution, partly because of their relatively efficient alveolar deposition and potential to enter the pulmonary vascular space. OBJECTIVES: This study tested the hypothesis that inhalation of elemental carbon UFP alters systemic vascular function. METHODS: Sixteen healthy subjects (mean age, 26.9 +/- 6.5 years) inhaled air or 50 mug/m(3) elemental carbon UFP by mouthpiece for 2 hr, while exercising intermittently. Measurements at preexposure baseline, 0 hr (immediately after exposure), 3.5 hr, 21 hr, and 45 hr included vital signs, venous occlusion plethysmography and reactive hyperemia of the forearm, and venous plasma nitrate and nitrite levels. RESULTS: Peak forearm blood flow after ischemia increased 3.5 hr after exposure to air but not UFP (change from preexposure baseline, air: 9.31 +/- 3.41; UFP: 1.09 +/- 2.55 mL/min/100 mL; t-test, p = 0.03). Blood pressure did not change, so minimal resistance after ischemia (mean blood pressure divided by forearm blood flow) decreased with air, but not UFP [change from preexposure baseline, air: -0.48 +/- 0.21; UFP: 0.07 +/- 0.19 mmHg/mL/min; analysis of variance (ANOVA), p = 0.024]. There was no UFP effect on pre-ischemia forearm blood flow or resistance, or on total forearm blood flow after ischemia. Venous nitrate levels were significantly lower after exposure to carbon UFP compared with air (ANOVA, p = 0.038). There were no differences in venous nitrite levels. CONCLUSIONS: Inhalation of 50 mug/m(3) carbon UFP during intermittent exercise impairs peak forearm blood flow during reactive hyperemia in healthy human subjects. pubtype: Academic Journal doctype: Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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