Neuromuscular and central nervous system manifestations of Clostridium perfringensi infections.
Infections with Clostridium perfringens usually manifest locally or spread to sepsis with multiorgan involvement, hemolysis or septic shock. Central nervous system (CNS) manifestations are rare and most frequently comprise meningitis with or without pneumencephalon, encephalitis, plexitis, cerebral...
| Publicado en: | Infection Vol. 35; no. 6; pp. 396 - 406 |
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| Autores principales: | , |
| Formato: | pictorial review tables/charts Journal Article |
| Publicado: |
Springer Nature
Dec2007
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=105727130&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 105727130 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 03008126 NXO jtl: Infection issn: 03008126 maglogo: N pubinfo: dt: Dec2007 vid: 35 iid: 6 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 105727130 105727130 2009753682 10.1007/s15010-007-6345-z NLM18034207 105727130 ppf: 396 ppct: 10 formats: fmt: @attributes: type: P tig: atl: Neuromuscular and central nervous system manifestations of Clostridium perfringensi infections. aug: au: Finsterer J Hess B affil: Neurological Department, Kaiser-Franz-Josef-Spital, Vienna, Austria sug: subj: Central Nervous System Infections Physiopathology Clostridium Clostridium Infections Physiopathology Central Nervous System Infections Epidemiology Central Nervous System Infections Microbiology Central Nervous System Infections Pathology Central Nervous System Infections Symptoms Central Nervous System Infections Therapy Clostridium Infections Epidemiology Clostridium Infections Microbiology Clostridium Infections Pathology Diagnosis, Differential Sepsis Risk Factors Surgical Wound Infection Physiopathology ab: Infections with Clostridium perfringens usually manifest locally or spread to sepsis with multiorgan involvement, hemolysis or septic shock. Central nervous system (CNS) manifestations are rare and most frequently comprise meningitis with or without pneumencephalon, encephalitis, plexitis, cerebral abscess, or subdural empyema. The course of CNS affections is usually foudroyant and the outcome fatal. Neuromuscular manifestations of C. perfringens infections are much more frequent than CNS manifestations and comprise myonecrosis (gas gangrene), rhabdomyolysis, myositis, fasciitis, affection of the neuromuscular transmission, or affection of the peripheral nerves. C. perfringens infections usually start from the site of a recent surgical wound or trauma, a gastrointestinal or urogenital problem, or occur in association with malignancy. In quite a number of cases the source of origin remains speculative. Treatment of choice is surgical debridement of the infectious focus with radical removal of all necrotic tissue, resection of the corresponding lymphatics in addition to antibiotic therapy with penicillin G, aminoglycosides, or clindamycin or hyperbaric oxygenation. Despite these therapeutic options, the prognosis of CNS and neuromuscular involvement in an infection with C. perfringens is still poor. Only focal infections or clostridial brain abscesses may eventually have a more favorable outcome, if surgery and antibiotics are instantly provided. Generally, early recognition of the infectious agent is of paramount importance to prevent from spreading and the development of severe hemolysis, septic shock, or death. pubtype: Academic Journal doctype: pictorial review tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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