Predictors of residual invasive disease after core needle biopsy diagnosis of ductal carcinoma in situ.
Core needle biopsy (CNB) is used to sample both mammographically and ultrasound detected breast lesions. A diagnosis of ductal carcinoma in situ (DCIS) by CNB does not ensure the absence of invasive cancer upon surgical excision and as a result an upstaged patient may need to undergo additional surg...
| Publicado en: | Breast Journal Vol. 13; no. 3; pp. 251 - 258 |
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| Autores principales: | , , , , , , , , , , , , |
| Formato: | research Journal Article |
| Publicado: |
Wiley-Blackwell
May/Jun2007
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=105731123&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 105731123 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 1075122X ET6 jtl: Breast Journal issn: 1075122X maglogo: Y pubinfo: dt: May/Jun2007 vid: 13 iid: 3 pid: 480 pub: Wiley-Blackwell place: Malden, Massachusetts artinfo: ui: 105731123 105731123 2009630197 10.1111/j.1524-4741.2007.00418.x NLM17461899 105731123 ppf: 251 ppct: 7 formats: fmt: @attributes: type: P tig: atl: Predictors of residual invasive disease after core needle biopsy diagnosis of ductal carcinoma in situ. aug: au: Rutstein LA Johnson RR Poller WR Dabbs D Groblewski J Rakitt T Tsung A Kirchner T Sumkin J Keenan D Soran A Ahrendt G Falk JS affil: Maine Medical Center, Portland, Maine 04102, USA. sug: subj: Adenocarcinoma Pathology Adenocarcinoma Biopsy, Needle Breast Neoplasms Pathology Precancerous Conditions Pathology Adult Aged Female Middle Age Neoplasm Invasiveness Neoplasm Metastasis Neoplastic Processes Physical Examination Predictive Value of Tests Prospective Studies Retrospective Design Human Adult: 19-44 years Aged: 65+ years Middle Aged: 45-64 years Female ab: Core needle biopsy (CNB) is used to sample both mammographically and ultrasound detected breast lesions. A diagnosis of ductal carcinoma in situ (DCIS) by CNB does not ensure the absence of invasive cancer upon surgical excision and as a result an upstaged patient may need to undergo additional surgery for axillary nodal evaluation. This study evaluates the accuracy of CNB in excluding invasive disease and the preoperative features that predict upstaging of DCIS to invasive breast cancer. Two hundred fifty-four patients over an 8-year period from 1994 to 2002 with a diagnosis of DCIS alone by CNB were retrospectively reviewed. Underestimation of invasive cancer by CNB was determined. Radiographic, pathologic, and surgical features of the cohort were compared using univariate and multivariate analysis. The mean age was 55 years (range 27-84) and mean follow-up was 25 months with one patient unavailable for follow-up. There were a total of six patient deaths, all of which were not disease-specific. A total of 21 out of 254 patients (8%) with DCIS by CNB were upstaged to invasive cancer following surgical excision. There was a significant inverse relationship between the number of core biopsies and the incidence of upstaging (p < 0.006) in that patients with fewer core samples were more likely to be upstaged at surgical pathology. No relationship was noted between the size of the core samples and the likelihood of upstaging (p > 0.4). Of 21 patients with invasion, all but two had comedonecrosis by CNB. Comedonecrosis by CNB significantly increased the likelihood of upstaging (p < 0.001). Of the 21 patients who were upstaged, 12 required subsequent surgery for nodal evaluation while nine had sentinel node biopsy at initial operation. Finally, upstaged patients were significantly more likely to have a positive margin (p < 0.008). Ductal carcinoma in situ with comedonecrosis on CNB can help to predict the possibility of invasion. Increasing the number of core biopsies reduced the likelihood of sampling error. pubtype: Academic Journal doctype: research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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