Puncture of a lumbar intervertebral disc induces changes in spontaneous pain behavior: an experimental study in rats.
STUDY DESIGN: Changes in spontaneous behavior was studied in rats after a controlled puncture of a lumbar intervertebral disc. OBJECTIVE: To study if puncture of a lumbar disc would induce recordable changes in spontaneous pain behavior. SUMMARY OF BACKGROUND DATA: Anular tears are common and may be...
| Publicado en: | Spine (03622436) Vol. 33; no. 8; pp. 850 - 856 |
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| Autor principal: | |
| Formato: | Journal Article |
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Lippincott Williams & Wilkins
4/15/2008
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=105731579&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 105731579 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 03622436 1Y6 jtl: Spine (03622436) issn: 03622436 maglogo: N pubinfo: dt: 4/15/2008 vid: 33 iid: 8 pid: 433 pub: Lippincott Williams & Wilkins place: Baltimore, Maryland artinfo: ui: 105731579 105731579 2009898684 10.1097/brs.0b013e31816b46ca NLM18404103 105731579 ppf: 850 ppct: 6 formats: tig: atl: Puncture of a lumbar intervertebral disc induces changes in spontaneous pain behavior: an experimental study in rats. aug: au: Olmarker K affil: Department of Orthopaedics, Institute of Clinical Sciences, Sahlgrenska Academy, Göteborg University, Gothenburg, Sweden. kjell.olmarker@orthop.gu.se sug: subj: Behavior Intervertebral Disk Displacement Psychosocial Factors Intervertebral Disk Injuries Pain Psychosocial Factors Wounds, Penetrating Psychosocial Factors Animals Grooming Physiology Hypokinesia Physiopathology Hypokinesia Psychosocial Factors Intervertebral Disk Displacement Etiology Intervertebral Disk Displacement Physiopathology Intervertebral Disk Physiopathology Lumbar Vertebrae Injuries Lumbar Vertebrae Pathology Models, Biological Motor Activity Physiology Pain Physiopathology Punctures Rats Wounds, Penetrating Complications Wounds, Penetrating Physiopathology ab: STUDY DESIGN: Changes in spontaneous behavior was studied in rats after a controlled puncture of a lumbar intervertebral disc. OBJECTIVE: To study if puncture of a lumbar disc would induce recordable changes in spontaneous pain behavior. SUMMARY OF BACKGROUND DATA: Anular tears are common and may be found both in patients with low back pain and in asymptomatic patients. It has been suggested that anular injury may relate to low back pain either by stimulation of local sensory receptors in the posterior part of the anulus fibrosus or by ingrowth of newly formed nerve fibers into the deeper parts of the disc. The objective of the study was to analyze if a controlled puncture of a lumbar intervertebral disc might induce recordable changes in spontaneous behavior of rats. METHODS: After anesthesia, the L4-L5 disc was punctured in 10 rats. Ten other rats received sham surgery. Spontaneous behavior was assessed at days 1, 3, 7, 14, and 21 after surgery. RESULTS: Statistically significant differences in behavior were seen at all days analyzed. Most consistent were increases in 'grooming' and in 'wet-dog shakes.' CONCLUSION: Puncture of a lumbar intervertebral disc in the rat produces changes in spontaneous behavior mainly seen as increased 'grooming' and 'wet-dog shakes,' 2 behaviors that have been suggested to indicate stress and pain. pubtype: Academic Journal doctype: Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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