Image-guided radiotherapy for liver cancer using respiratory-correlated computed tomography and cone-beam computed tomography.
Purpose: To evaluate a novel four-dimensional (4D) image-guided radiotherapy (IGRT) technique in stereotactic body RT for liver tumors. Methods and Materials: For 11 patients with 13 intrahepatic tumors, a respiratory-correlated 4D computed tomography (CT) scan was acquired at treatment planning. Th...
| Publicado en: | International Journal of Radiation Oncology, Biology, Physics Vol. 71; no. 1; pp. 297 - 305 |
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| Autores principales: | , , , , , , , , , , , , , , , , , |
| Formato: | research Journal Article |
| Publicado: |
Pergamon Press - An Imprint of Elsevier Science
May2008
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=105746609&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 105746609 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 03603016 1ZQ jtl: International Journal of Radiation Oncology, Biology, Physics issn: 03603016 maglogo: N pubinfo: dt: May2008 vid: 71 iid: 1 pid: 2410 pub: Pergamon Press - An Imprint of Elsevier Science artinfo: ui: 105746609 105746609 NLM18406894 2009916644 10.1016/j.ijrobp.2008.01.005 NLM18406894 105746609 ppf: 297 ppct: 8 formats: tig: atl: Image-guided radiotherapy for liver cancer using respiratory-correlated computed tomography and cone-beam computed tomography. aug: au: Guckenberger M Sweeney RA Wilbert J Krieger T Richter A Baier K Mueller G Sauer O Flentje M Guckenberger, Matthias Sweeney, Reinhart A Wilbert, Juergen Krieger, Thomas Richter, Anne Baier, Kurt Mueller, Gerd Sauer, Otto Flentje, Michael affil: Department of Radiation Oncology, Julius-Maximilians University, Wuerzburg, Germany sug: subj: Diagnostic Imaging Methods Liver Neoplasms Radiography Liver Neoplasms Radiotherapy Liver Neoplasms Radiotherapy, Computer-Assisted Methods Respiration Stereotaxic Techniques Tomography, X-Ray Computed Methods Adult Aged Carcinoma, Hepatocellular Radiography Carcinoma, Hepatocellular Radiotherapy Female Male Middle Age Movement Observer Bias Human Adult: 19-44 years Aged: 65+ years Middle Aged: 45-64 years Female Male ab: Purpose: To evaluate a novel four-dimensional (4D) image-guided radiotherapy (IGRT) technique in stereotactic body RT for liver tumors. Methods and Materials: For 11 patients with 13 intrahepatic tumors, a respiratory-correlated 4D computed tomography (CT) scan was acquired at treatment planning. The target was defined using CT series reconstructed at end-inhalation and end-exhalation. The liver was delineated on these two CT series and served as a reference for image guidance. A cone-beam CT scan was acquired after patient positioning; the blurred diaphragm dome was interpreted as a probability density function showing the motion range of the liver. Manual contour matching of the liver structures from the planning 4D CT scan with the cone-beam CT scan was performed. Inter- and intrafractional uncertainties of target position and motion range were evaluated, and interobserver variability of the 4D-IGRT technique was tested. Results: The workflow of 4D-IGRT was successfully practiced in all patients. The absolute error in the liver position and error in relation to the bony anatomy was 8 +/- 4 mm and 5 +/- 2 mm (three-dimensional vector), respectively. Margins of 4-6 mm were calculated for compensation of the intrafractional drifts of the liver. The motion range of the diaphragm dome was reproducible within 5 mm for 11 of 13 lesions, and the interobserver variability of the 4D-IGRT technique was small (standard deviation, 1.5 mm). In 4 patients, the position of the intrahepatic lesion was directly verified using a mobile in-room CT scanner after application of intravenous contrast. Conclusion: The results of our study have shown that 4D image guidance using liver contour matching between respiratory-correlated CT and cone-beam CT scans increased the accuracy compared with stereotactic positioning and compared with IGRT without consideration of breathing motion. pubtype: Academic Journal doctype: research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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