Imaging of small spherical structures in CT: simulation study using measured point spread function.

Size and density measurements of objects undertaken using computed tomography (CT) are clinically significant for diagnosis. To evaluate the accuracy of these quantifications, we simulated three-dimensional (3D) CT image blurring; this involved the calculation of the convolution of the 3D object fun...

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Publicado en:Medical & Biological Engineering & Computing Vol. 46; no. 3; pp. 273 - 283
Autores principales: Ohkubo M, Wada S, Kunii M, Matsumoto T, Nishizawa K, Ohkubo, Masaki, Wada, Shinichi, Kunii, Masayuki, Matsumoto, Toru, Nishizawa, Kanae
Formato: research Journal Article
Publicado: Springer Nature Mar2008
Acceso en línea:Ver este registro en EBSCOhost
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      pub: Springer Nature
      place: New York, New York
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        atl: Imaging of small spherical structures in CT: simulation study using measured point spread function.
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        au:
          Ohkubo M
          Wada S
          Kunii M
          Matsumoto T
          Nishizawa K
          Ohkubo, Masaki
          Wada, Shinichi
          Kunii, Masayuki
          Matsumoto, Toru
          Nishizawa, Kanae
        affil: Department of Radiological Technology, School of Health Sciences, Faculty of Medicine, Niigata University, Niigata, Japan
      sug:
        subj:
          Image Interpretation, Computer Assisted Methods
          Tomography, X-Ray Computed Methods
          Algorithms
          Diagnostic Imaging Methods
          Phantoms, Imaging
          Reproducibility of Results
          Human
      ab: Size and density measurements of objects undertaken using computed tomography (CT) are clinically significant for diagnosis. To evaluate the accuracy of these quantifications, we simulated three-dimensional (3D) CT image blurring; this involved the calculation of the convolution of the 3D object function with the measured 3D point spread function (PSF). We initially validated the simulation technique by performing a phantom experiment. Blurred computed images showed good 3D agreement with measured images of the phantom. We used this technique to compute the 3D blurred images from the object functions, in which functions are determined to have the shape of an ideal sphere of varying diameter and assume solitary pulmonary nodules with a uniform density. The accuracy of diameter and density measurements was determined. We conclude that the proposed simulation technique enables us to estimate the image blurring precisely of any 3D structure and to analyze clinical images quantitatively.
      pubtype: Academic Journal
      doctype:
        research
        Journal Article
      ougenre: Article
    language: English
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