Characterization of phthalate exposure among pregnant women assessed by repeat air and urine samples.
BACKGROUND: Although urinary concentrations of phthalate metabolites are frequently used as biomarkers in epidemiologic studies, variability during pregnancy has not been characterized. METHODS: We measured phthalate metabolite concentrations in spot urine samples collected from 246 pregnant Dominic...
| Publicado en: | Environmental Health Perspectives Vol. 116; no. 4; pp. 467 - 474 |
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| Autores principales: | , , , , , , , , , , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
National Institute of Environmental Health Sciences
Apr2008
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=105763746&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 105763746 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 00916765 3B5 jtl: Environmental Health Perspectives issn: 00916765 maglogo: N pubinfo: dt: Apr2008 vid: 116 iid: 4 pid: 56539 pub: National Institute of Environmental Health Sciences place: Research Triangle Park, North Carolina artinfo: ui: 105763746 105763746 2009892216 10.1289/ehp.10749 NLM18414628 105763746 ppf: 467 ppct: 7 formats: fmt: @attributes: type: P tig: atl: Characterization of phthalate exposure among pregnant women assessed by repeat air and urine samples. aug: au: Adibi JJ Whyatt RM Williams PL Calafat AM Camann D Herrick R Nelson H Bhat HK Perera FP Silva MJ Hauser R affil: Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts, USA sug: subj: Air Pollution, Indoor Carboxylic Acids Urine Confidence Intervals Female Funding Source Infant, Newborn Intraclass Correlation Coefficient New York Pregnancy Repeated Measures Sensitivity and Specificity Human Infant, Newborn: birth-1 month Female ab: BACKGROUND: Although urinary concentrations of phthalate metabolites are frequently used as biomarkers in epidemiologic studies, variability during pregnancy has not been characterized. METHODS: We measured phthalate metabolite concentrations in spot urine samples collected from 246 pregnant Dominican and African-American women. Twenty-eight women had repeat urine samples collected over a 6-week period. We also analyzed 48-hr personal air samples (n = 96 women) and repeated indoor air samples (n = 32 homes) for five phthalate diesters. Mixed-effects models were fit to evaluate reproducibility via intraclass correlation coefficients (ICC). We evaluated the sensitivity and specificity of using a single specimen versus repeat samples to classify a woman's exposure in the low or high category. RESULTS: Phthalates were detected in 85-100% of air and urine samples. ICCs for the unadjusted urinary metabolite concentrations ranged from 0.30 for mono-ethyl phthalate to 0.66 for monobenzyl phthalate. For indoor air, ICCs ranged from 0.48 [di-2-ethylhexyl phthalate (DEHP)] to 0.83 [butylbenzyl phthalate (BBzP)]. Air levels of phthalate diesters correlated with their respective urinary metabolite concentrations for BBzP (r = 0.71), di-isobutyl phthalate (r = 0.44), and diethyl phthalate (DEP; r = 0.39). In women sampled late in pregnancy, specific gravity appeared to be more effective than creatinine in adjusting for urine dilution. CONCLUSIONS: Urinary concentrations of DEP and DEHP metabolites in pregnant women showed lower reproducibility than metabolites for di-n-butyl phthalate and BBzP. A single indoor air sample may be sufficient to characterize phthalate exposure in the home, whereas urinary phthalate biomarkers should be sampled longitudinally during pregnancy to minimize exposure misclassification. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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