Working memory and multi-tasking in paranoid schizophrenia with and without comorbid substance use disorder.
AIMS: Addiction is a frequent comorbid disorder in schizophrenia and associated with poor outcome. The present study sought to determine whether addicted and non-addicted schizophrenic patients are impaired differentially on the executive abilities of working memory and multi-tasking which are relev...
| Publicado en: | Addiction Vol. 103; no. 5; pp. 774 - 787 |
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| Autores principales: | , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
Wiley-Blackwell
May2008
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=105776172&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 105776172 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 09652140 AIO jtl: Addiction issn: 09652140 maglogo: Y pubinfo: dt: May2008 vid: 103 iid: 5 pid: 480 pub: Wiley-Blackwell place: Malden, Massachusetts artinfo: ui: 105776172 2009921483 10.1111/j.1360-0443.2008.02156.x NLM18412756 105776172 ppf: 774 ppct: 13 formats: fmt: @attributes: type: P tig: atl: Working memory and multi-tasking in paranoid schizophrenia with and without comorbid substance use disorder. aug: au: Thoma P Daum I affil: Institute of Cognitive Neuroscience, Department of Neuropsychology, Ruhr-University of Bochum, Germany. patrizia.thoma@rub.de sug: subj: Cognition Evaluation Comorbidity Memory Evaluation Schizophrenia Psychosocial Factors Substance Use Disorders Task Performance and Analysis Adult Analysis of Covariance Analysis of Variance Attention Case Control Studies Chi Square Test Coefficient alpha Data Analysis Software Descriptive Statistics Female Funding Source Inpatients Kruskal-Wallis Test Male Mann-Whitney U Test Middle Age Pearson's Correlation Coefficient Post Hoc Analysis Psychological Tests Reaction Time Record Review Repeated Measures Scales Self Report Semi-Structured Interview Severity of Illness Indices T-Tests Two-Tailed Test Wechsler Adult Intelligence Scale-Revised Human Adult: 19-44 years Middle Aged: 45-64 years Female Male ab: AIMS: Addiction is a frequent comorbid disorder in schizophrenia and associated with poor outcome. The present study sought to determine whether addicted and non-addicted schizophrenic patients are impaired differentially on the executive abilities of working memory and multi-tasking which are relevant for maintaining abstinence. DESIGN: Comparisons of executive performance in clinical and control groups. SETTING: In-patient setting. PARTICIPANTS: The cognitive profile of schizophrenic patients with and without comorbid substance abuse disorder was compared with that of patients suffering from major depression or alcoholism and healthy participants. MEASUREMENTS: A range of cognitive tasks was used to assess: (i) the ability to update continuously context information in working memory and to use it for action selection; and (ii) the capacity to divide attention between different sensory input channels and to coordinate verbal and manual responses. FINDINGS: Single-diagnosis schizophrenic patients showed pronounced impairments on measures of online maintenance and use of context information. Their ability to coordinate different sensory input channels (divided attention) was also impaired. Addicted schizophrenics showed evidence of impaired sensory input management and of reduced context sensitivity, when age differences were controlled. CONCLUSIONS: The present study indicates severe working memory and multi-tasking deficits in schizophrenia which are, however, not exacerbated by comorbid addiction. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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