Seroepidemiology and molecular characterization of hepatitis E virus in Jilin, China.
In order to develop region-specific diagnostic assays and prevent hepatitis E virus (HEV), it is essential to understand epidemiology and genotypic variation within different populations. However, the epidemiological data of HEV infections in Jilin is shortage. The seroepidemiological study was cond...
| Publicado en: | Infection Vol. 36; no. 2; pp. 140 - 147 |
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| Autores principales: | , , , , , , , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
Springer Nature
Apr2008
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=105788871&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 105788871 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 03008126 NXO jtl: Infection issn: 03008126 maglogo: N pubinfo: dt: Apr2008 vid: 36 iid: 2 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 105788871 2009899590 10.1007/s15010-007-7130-8 NLM18330507 105788871 ppf: 140 ppct: 7 formats: fmt: @attributes: type: P tig: atl: Seroepidemiology and molecular characterization of hepatitis E virus in Jilin, China. aug: au: Zhu G Qu Y Jin N Sun Z Liu T Lee H Tian M Wang T affil: Genetic Engineering Laboratory, Academy of Military Medical Sciences, 1068 Qinglong Road Changchun 130062, People's Republic of China sug: subj: Genotype Hepatitis E Epidemiology Hepatitis Viruses Classification Adolescence Adult Age Factors Aged Aged, 80 and Over Chi Square Test Child China Data Analysis Software Descriptive Statistics Epidemiological Research Female Funding Source Hepatitis E Risk Factors Hepatitis Viruses Transmission Immunoassay Immunoglobulins Blood Male Middle Age Polymerase Chain Reaction Seroprevalence Studies Sex Factors Human Adolescent: 13-18 years Adult: 19-44 years Aged: 65+ years Aged, 80 & over Child: 6-12 years Middle Aged: 45-64 years Female Male ab: In order to develop region-specific diagnostic assays and prevent hepatitis E virus (HEV), it is essential to understand epidemiology and genotypic variation within different populations. However, the epidemiological data of HEV infections in Jilin is shortage. The seroepidemiological study was conducted by enzyme-linked immunosorbent assay, and the conserved genomic sequences of open reading frame 2 (348 bp) was detected using reverse transcription-PCR. Overall, 1,289 serum samples were positive to HEV-specific immunoglobulin G (IgG), and 180 serum samples were positive to HEV-specific immunoglobulin M (IgM). The seroprevalence of HEV-specific IgG was 26.3%, 27.9%, 25.3%, 32.7% in 2003, 2004, 2005, 2006, respectively. Acute HEV infection mainly occurred in male, people aged from 20 to 69 were more susceptible to infection, and cases with IgM anti-HEV reaction mainly occurred from July to November. HEV RNA was detectable in the serum samples or stool suspension of 15 patients with HEV-specific IgM, and all of these belonged to genotype IV. Our results indicate that HEV is widely spread in Jilin and confined to genotype IV. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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