A novel automated approach to enabling high-throughput cell line development, selection, and other cell culture tasks performed in Erlenmeyer (shake) flasks.
Selection of the optimum cell line from large populations can be time consuming and laborious. Compromises are often necessary to meet challenging timelines, but can limit the parameters or cell line construction strategies that can be evaluated. This article describes a new automated cell culture s...
| Publicado en: | JALA: Journal of the Association for Laboratory Automation Vol. 13; no. 3; pp. 145 - 152 |
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| Autores principales: | , , , , , |
| Formato: | pictorial research tables/charts Journal Article |
| Publicado: |
Elsevier B.V.
Jun2008
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=105804961&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 105804961 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 15355535 YU9 jtl: JALA: Journal of the Association for Laboratory Automation issn: 15355535 maglogo: N pubinfo: dt: Jun2008 vid: 13 iid: 3 pid: 467 pub: Elsevier B.V. place: New York, New York artinfo: ui: 105804961 2009952951 10.1016/j.jala.2008.01.003 105804961 ppf: 145 ppct: 7 formats: tig: atl: A novel automated approach to enabling high-throughput cell line development, selection, and other cell culture tasks performed in Erlenmeyer (shake) flasks. aug: au: Thomas D Ward T Drake R Hollway R Savage D Owen S affil: The Automation Partnership, York Way, Royston, Hertfordshire, SG8 5WY, UK; dave.thomas@automationpartnership.com sug: subj: Automation Tissue Culture Techniques Tissue Culture Techniques Equipment and Supplies Drug Design Equipment Design Evaluation Research Funding Source Software Systems Design Human ab: Selection of the optimum cell line from large populations can be time consuming and laborious. Compromises are often necessary to meet challenging timelines, but can limit the parameters or cell line construction strategies that can be evaluated. This article describes a new automated cell culture system for cell line selection and characterization. The technologies enable data to be obtained from large numbers of cells lines allowing users to evaluate, in parallel, a wider range of molecular approaches and cell culture processes. This facilitates more rapid and efficient cell line development. Also, presented are initial biological testing data for the new system and descriptions of how highly parallel processing can contribute to significantly reduced cycle times and better decision making through the rapid identification of optimum cell lines and culture conditions. pubtype: Academic Journal doctype: pictorial research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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