Comparison of Narcotrend Index, Bispectral Index, spectral and entropy parameters during induction of propofol-remifentanil anaesthesia.
Objective: This study investigated the suitability of various electroencephalogram (EEG) parameters to describe anaesthetic drug effects in propofol-remifentanil anaesthesia. The investigated parameters were the Narcotrend Index (NI), the Bispectral Index (BIS), and standard spectral and entropy par...
| Published in: | Journal of Clinical Monitoring & Computing Vol. 22; no. 2; pp. 103 - 112 |
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| Main Authors: | , , , , , , , , , |
| Format: | clinical trial research Journal Article |
| Published: |
Springer Nature
Apr2008
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| Online Access: | View this record in EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=105808641&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 105808641 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 13871307 OHC jtl: Journal of Clinical Monitoring & Computing issn: 13871307 maglogo: N pubinfo: dt: Apr2008 vid: 22 iid: 2 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 105808641 32620284 NLM18288579 2009891472 10.1007/s10877-008-9111-6 NLM18288579 105808641 ppf: 103 ppct: 9 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Comparison of Narcotrend Index, Bispectral Index, spectral and entropy parameters during induction of propofol-remifentanil anaesthesia. aug: au: Schultz A Siedenberg M Grouven U Kneif T Schultz B Schultz, Arthur Siedenberg, Markus Grouven, Ulrich Kneif, Thomas Schultz, Barbara affil: Department of Medical Informatics and Biometry, Klinikum Region Hannover, Hannover, Germany sug: subj: Anesthesiology Methods Intraoperative Monitoring Methods Piperidines Administration and Dosage Propofol Administration and Dosage Adolescence Adult Aged Anesthetics, Intravenous Administration and Dosage Clinical Assessment Tools Clinical Trials Cognition Drug Effects Drug Monitoring Methods Electroencephalography Female Hypnosis, Anesthetic Male Middle Age Physics Predictive Value of Tests Sex Factors Time Factors Weights and Measures Human Adolescent: 13-18 years Adult: 19-44 years Aged: 65+ years Middle Aged: 45-64 years Female Male ab: Objective: This study investigated the suitability of various electroencephalogram (EEG) parameters to describe anaesthetic drug effects in propofol-remifentanil anaesthesia. The investigated parameters were the Narcotrend Index (NI), the Bispectral Index (BIS), and standard spectral and entropy parameters. Additionally, it was investigated whether the effect of a fixed dosage of propofol on the attained depth of hypnosis during induction of anaesthesia is different in male and female patients.Methods: Standardized inductions of anaesthesia in 10 male and 10 female patients (ASA status I or II, 15-75 years) were analysed. All patients received 4 mg propofol/kg over 6 min followed by 4 mg/kg/h. For analgesia, patients received 0.3 microg/kg/min remifentanil starting 2 min before propofol application. For EEG monitoring, the Narcotrend and the Aspect A-2,000 Bispectral Index monitor were used simultaneously. Data from start of propofol injection until 1 min after the end of the induction period (420 s) were used for statistical analysis. EEG parameters were evaluated every 10 s.Results: The Narcotrend Index and the Bispectral Index had the highest mean correlations with the calculated propofol effect-site concentration and were able to distinguish stages from the awake state or the near awake state and stages of deep hypnosis. On the Narcotrend scale, more data points are available for levels of anaesthesia with relevance for maintenance of anaesthesia. The BIS values at the first occurrence of burst suppression were significantly higher than the corresponding NI values. During induction of anaesthesia, the same dosages of propofol (per kg body weight) given to men and women did not show different effects on the EEG.Conclusions: NI and BIS are superior to spectral and entropy parameters in describing changes of propofol concentration during induction of propofol-remifentanil anaesthesia. pubtype: Academic Journal doctype: clinical trial research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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