Impact of bacterial and fungal donor organ contamination in lung, heart-lung, heart and liver transplantation.
We investigated to which extent bacterial and fungal donor organ contamination (DOC) caused posttransplant nosocomial infections (NI) in solid organ transplant (Tx) recipients. Between January 2002 to December 2003 (lung and heart Tx) and October 2003 to September 2004 (liver Tx), NIs were determine...
| Publicado en: | Infection Vol. 36; no. 3; pp. 207 - 213 |
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| Autores principales: | , , , , , , , , , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
Springer Nature
Jun2008
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=105812661&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 105812661 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 03008126 NXO jtl: Infection issn: 03008126 maglogo: N pubinfo: dt: Jun2008 vid: 36 iid: 3 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 105812661 105812661 2009962303 10.1007/s15010-007-7157-x NLM18470477 105812661 ppf: 207 ppct: 6 formats: fmt: @attributes: type: P tig: atl: Impact of bacterial and fungal donor organ contamination in lung, heart-lung, heart and liver transplantation. aug: au: Mattner F Kola A Fischer S Becker T Haverich A Simon A Suerbaum S Gastmeier P Weißbrodt H Strüber M affil: Institute for Medical Microbiology and Hospital Epidemiology, Universitat zu Lubeck, Lubeck, Germany sug: subj: Cross Infection Epidemiology Heart Liver Lung Microbial Contamination Organ Transplantation Adverse Effects Academic Medical Centers Adult Antibiotic Prophylaxis Chi Square Test Confidence Intervals Convenience Sample Data Analysis Software Descriptive Statistics Female Fisher's Exact Test Genotype Classification Germany Male Microbial Culture and Sensitivity Tests Middle Age Prospective Studies Human Adult: 19-44 years Middle Aged: 45-64 years Female Male ab: We investigated to which extent bacterial and fungal donor organ contamination (DOC) caused posttransplant nosocomial infections (NI) in solid organ transplant (Tx) recipients. Between January 2002 to December 2003 (lung and heart Tx) and October 2003 to September 2004 (liver Tx), NIs were determined according to modified CDC criteria for NIs for all transplantations performed at Hannover Medical School. Organisms of the same species cultured from donor organs and infected transplantees were genotyped if available. Out of 282 solid organ recipients (140 lung-Tx, 16 heart-lung-Tx, 51 heart-Tx, 75 liver-Tx), 150 recipients (53.2%) received contaminated donor organs. Incidences of NIs were 33.7% in lung, 68.8% in heart-lung, 21.6% in heart, and 28% in liver recipients. In 11 out of 282 transplantees (3.9%, CI 95% 2.0-6.9%) organisms of NIs and of contamination of the donor organ were of the same species. Even if assuming five missing pairs of organisms as genetically identical, incidences of DOC-related posttransplant infections were only between 1.3% (CI95% 0.0; 7.2) in liver-Tx and 18.8% (CI95% 4; 45.6) in heart-lung Tx, and DOC related mortality was 0.4% (CI95% 0.0;1.9). Despite high DOC rates, posttransplant infections due to DOC were rare under the condition of adequate preoperative antibiotic prophylaxis and aseptic organ retrievement. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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