Red Wine, but not port wine, protects rat hippocampal dentate gyrus against ethanol-induced neuronal damage--relevance of the sugar content.
Aims: Chronic ethanol consumption leads to oxidative damage in the central nervous system inducing neuronal degeneration and impairment of brain functions. Nevertheless, it has been reported that grape polyphenols might prevent the alluded ethanol effects. We have reported that prolonged red wine in...
| Publicado en: | Alcohol & Alcoholism Vol. 43; no. 4; pp. 408 - 416 |
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| Autores principales: | , , , , |
| Formato: | Journal Article |
| Publicado: |
Oxford University Press / USA
Jul/Aug2008
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=105814989&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 105814989 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 07350414 FA3 jtl: Alcohol & Alcoholism issn: 07350414 maglogo: N pubinfo: dt: Jul/Aug2008 vid: 43 iid: 4 pid: 622 pub: Oxford University Press / USA artinfo: ui: 105814989 105814989 2010011375 10.1093/alcalc/agn024 NLM18445757 105814989 ppf: 408 ppct: 8 formats: fmt: @attributes: type: P tig: atl: Red Wine, but not port wine, protects rat hippocampal dentate gyrus against ethanol-induced neuronal damage--relevance of the sugar content. aug: au: Carneiro A Assunçao M De Freitas V Paula-Barbosa MM Andrade JP affil: Department of Anatomy, Faculty of Medicine, University of Porto, Al. Prof. Hernâni Monteiro, 4200-319 Porto, Portugal. sug: subj: Ethanol Pharmacodynamics Ethanol Carbohydrates Analysis Hippocampus Drug Effects Hippocampus Metabolism Oxidative Stress Drug Effects Wine Classification Animals Hippocampus Male Neurons Drug Effects Neurons Metabolism Neurons Rats Male ab: Aims: Chronic ethanol consumption leads to oxidative damage in the central nervous system inducing neuronal degeneration and impairment of brain functions. Nevertheless, it has been reported that grape polyphenols might prevent the alluded ethanol effects. We have reported that prolonged red wine intake improves hippocampal formation oxidative status, a finding not replicated using Port wine. Thus, we thought of interest to compare the effects of chronic ingestion of these wines in the morphology of dentate gyrus (DO) neurons that are particularly vulnerable to alcohol effects. Methods: Six-month-old Wistar rats were fed either with red wine or Port wine (both with 20% ethanol content, v/v), and the results were compared with 20% (v/v) ethanol-treated, ethanol/glucose and pair-fed control groups. After 6 months of treatment, the layer volumes of the DO and the total number of granule and hilar neurons were estimated. The dendntic trees of granule cells were also studied in Golgi-impregnated material. Results: The number of granule cells and the DO layer volumes were similar among all groups. However, the number of hilar neurons was reduced in Port wine, ethanol-treated and ethanol/glucose animals. Furthermore, the granule cells from these groups showed a decrease in the total dendritic length. Conclusions: Although the Port wine and red wine have similar amounts of flavanols with identical ability to protect against oxidative stress, the differences observed are probably related to the very dissimilar processes of wine production, leading in Port wine to a high content of sugars, which are known to have potent pro-oxidant effects. pubtype: Academic Journal doctype: Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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