Physicochemical compatibility of propofol with thiopental sodium.
The physicochemical compatibility of propofol and thiopental sodium when mixed together in various ratios and stored was studied. Mixtures of propofol and thiopental sodium in five volume ratios from 1:3 to 3:1 were refrigerated (4 degrees C) for up to seven days and then centrifuged at 2000g for tw...
| Publicado en: | American Journal of Health-System Pharmacy Vol. 53; no. 21; pp. 2606 - 2611 |
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| Autores principales: | , |
| Formato: | Journal Article |
| Publicado: |
Oxford University Press / USA
1996 Nov 1
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=105817738&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 105817738 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 10792082 1X3 jtl: American Journal of Health-System Pharmacy issn: 10792082 maglogo: N pubinfo: dt: 1996 Nov 1 vid: 53 iid: 21 pid: 622 pub: Oxford University Press / USA artinfo: ui: 105817738 2009791805 NLM8913389 105817738 ppf: 2606 ppct: 5 formats: tig: atl: Physicochemical compatibility of propofol with thiopental sodium. aug: au: Prankerd RJ Jones RD affil: Department of Pharmacy, University of Queensland, St. Lucia, Australia. richard.prankerd@pharmacy.uq.edu.au sug: subj: Anesthetics, Intravenous Propofol Thiopental Chromatography, High Pressure Liquid Methods Drug Combinations Drug Stability Drug Synergism Drug Therapy, Combination Hydrogen-Ion Concentration Solutions Time Factors ab: The physicochemical compatibility of propofol and thiopental sodium when mixed together in various ratios and stored was studied. Mixtures of propofol and thiopental sodium in five volume ratios from 1:3 to 3:1 were refrigerated (4 degrees C) for up to seven days and then centrifuged at 2000g for two hours. Droplet sizes were determined at intervals by optical microscopy and laser diffraction, and chemical stability of the 1:1 mixture was evaluated by high-performance liquid chromatography (HPLC). Optical microscopy and laser diffraction indicated negligible changes in droplet size within 48 hours of mixing. A small increase in the width of the frequency distribution of droplet sizes occurred 24-48 hours after mixing for the two mixtures with the lowest propofol concentration. Some coalescence of droplets occurred on centrifugation. These results indicated negligible formation of droplets that might cause embolism after i.v. injection of fresh mixtures (not more than six hours old). A yellow color appearing after 24-48 hours indicated anticipated chemical changes. HPLC of samples stored at 25 degrees C indicated clinically unimportant drug loss after six hours. The mixtures were considered physically stable for not more than 48 hours. Droplet size in mixtures of propofol and thiopental sodium did not increase until at least 24 hours. Drug loss from mixtures containing propofol 5 mg/mL and thiopental sodium 12.5 mg/mL was insignificant for up to eight hours. pubtype: Academic Journal doctype: Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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