Cerebral metabolism and mood in remitted opiate dependence.
Background: Opiate-dependent individuals are prone to dysphoria that may contribute to treatment failure. Methadone-maintenance therapy (MMT) may mitigate this vulnerability, but controversy surrounds its long-term use. Little is known about the neurobiology of mood dysregulation in individuals rece...
| Published in: | Drug & Alcohol Dependence Vol. 90; no. 2/3; pp. 166 - 175 |
|---|---|
| Main Authors: | , , , , , , , , , , , , , , , , , , , |
| Format: | research Journal Article |
| Published: |
Elsevier B.V.
Oct2007
|
| Online Access: | View this record in EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=105826265&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 105826265 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 03768716 3S6 jtl: Drug & Alcohol Dependence issn: 03768716 maglogo: N pubinfo: dt: Oct2007 vid: 90 iid: 2/3 pid: 1004 pub: Elsevier B.V. artinfo: ui: 105826265 NLM17521829 2009683233 10.1016/j.drugalcdep.2007.03.015 NLM17521829 PMC2063442 105826265 ppf: 166 ppct: 9 formats: tig: atl: Cerebral metabolism and mood in remitted opiate dependence. aug: au: Galynker II Eisenberg D Matochik JA Gertmenian-King E Cohen L Kimes AS Contoreggi C Kurian V Ernst M Rosenthal RN Prosser J London ED Galynker, Igor I Eisenberg, Daniel Matochik, John A Gertmenian-King, Enid Cohen, Lisa Kimes, Alane S Contoreggi, Carlo Kurian, Varughese affil: Department of Psychiatry and Behavioral Sciences, Beth Israel Medical Center, Albert Einstein College of Medicine, First Avenue at 16th Street, New York, NY 10003, USA sug: subj: Affect Brain Metabolism Substance Use Disorders Psychosocial Factors Substance Use Disorders Rehabilitation Adult Disease Remission Dysthymic Disorder Diagnosis Dysthymic Disorder Epidemiology Dysthymic Disorder Psychosocial Factors Female Fludeoxyglucose F 18 Diagnostic Use Fludeoxyglucose F 18 Pharmacokinetics Male Methadone Therapeutic Use Narcotics Therapeutic Use Questionnaires Radiopharmaceuticals Diagnostic Use Radiopharmaceuticals Pharmacokinetics Tomography, Emission-Computed Human Adult: 19-44 years Female Male ab: Background: Opiate-dependent individuals are prone to dysphoria that may contribute to treatment failure. Methadone-maintenance therapy (MMT) may mitigate this vulnerability, but controversy surrounds its long-term use. Little is known about the neurobiology of mood dysregulation in individuals receiving or removed from MMT.Methods: Fifteen opiate-abstinent and 12 methadone-maintained, opiate-dependent subjects, who lacked other Axis I pathology, and 13 control subjects were compared on the Cornell Dysthymia Rating Scale (CDRS) and regional cerebral glucose metabolism (rCMRglc) using [(18)F]fluorodeoxyglucose positron emission tomography.Results: CDRS scores showed no group differences. Opiate-abstinent subjects had lower rCMRglc than control subjects in the bilateral perigenual anterior cingulate cortex (ACC), left mid-cingulate cortex, left insula and right superior frontal cortex. Methadone-maintained subjects exhibited lower rCMRglc than control subjects in the left insula and thalamus. In opiate-abstinent subjects, rCMRglc in the left perigenual ACC and mid-cingulate cortex correlated positively with CDRS scores.Conclusions: In remitted heroin dependence, opiate-abstinence is associated with more widespread patterns of abnormal cortical activity than MMT. Aberrant mood processing in the left perigenual ACC and mid-cingulate cortex, seen in opiate-abstinent individuals, is absent in those receiving MMT, suggesting that methadone may improve mood regulation in this population. pubtype: Academic Journal doctype: research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
|---|