Maternal Residence Near Agricultural Pesticide Applications and Autism Spectrum Disorders among Children in the California Central Valley.
BACKGROUND: Ambient levels of pesticides ('pesticide drift') are detectable at residences near agricultural field sites. OBJECTIVE: Our goal was to evaluate the hypothesis that maternal residence near agricultural pesticide applications during key periods of gestation could be associated with the de...
| Publicado en: | Environmental Health Perspectives Vol. 115; no. 10; pp. 1482 - 1490 |
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| Autores principales: | , , , , , |
| Formato: | research Journal Article |
| Publicado: |
National Institute of Environmental Health Sciences
Oct2007
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=105846184&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 105846184 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 00916765 3B5 jtl: Environmental Health Perspectives issn: 00916765 maglogo: N pubinfo: dt: Oct2007 vid: 115 iid: 10 pid: 56539 pub: National Institute of Environmental Health Sciences place: Research Triangle Park, North Carolina artinfo: ui: 105846184 105846184 2009688920 10.1289/ehp.10168 NLM17938740 105846184 ppf: 1482 ppct: 8 formats: fmt: @attributes: type: P tig: atl: Maternal Residence Near Agricultural Pesticide Applications and Autism Spectrum Disorders among Children in the California Central Valley. aug: au: Roberts EM English PB Grether JK Windham GC Somberg L Wolff C affil: Public Health Institute, Oakland, California, USA. sug: subj: Autism Spectrum Disorder Epidemiology Environmental Exposure Adverse Effects Hydrocarbons, Chlorinated Pesticides Prenatal Exposure Delayed Effects Residence Characteristics Adult California Case Control Studies Child Dose-Response Relationship, Drug Female Odds Ratio Pregnancy Prospective Studies Resource Databases Rural Population Human Adult: 19-44 years Child: 6-12 years Female ab: BACKGROUND: Ambient levels of pesticides ('pesticide drift') are detectable at residences near agricultural field sites. OBJECTIVE: Our goal was to evaluate the hypothesis that maternal residence near agricultural pesticide applications during key periods of gestation could be associated with the development of autism spectrum disorders (ASD) in children. METHODS: We identified 465 children with ASD born during 1996-1998 using the California Department of Developmental Services electronic files, and matched them by maternal date of last menstrual period to 6,975 live-born, normal-birth-weight, term infants as controls. We determined proximity to pesticide applications using California Department of Pesticide Regulation records refined using Department of Water Resources land use polygons. A staged analytic design applying a priori criteria to the results of conditional logistic regressions was employed to exclude associations likely due to multiple testing error. RESULTS: Of 249 unique hypotheses, four that described organochlorine pesticide applications--specifically those of dicofol and endosulfan--occurring during the period immediately before and concurrent with central nervous system embryogenesis (clinical weeks 1 through 8) met a priori criteria and were unlikely to be a result of multiple testing. Multivariate a posteriori models comparing children of mothers living within 500 m of field sites with the highest nonzero quartile of organochlorine poundage to those with mothers not living near field sites suggested an odds ratio for ASD of 6.1 (95% confidence interval, 2.4-15.3). ASD risk increased with the poundage of organochlorine applied and decreased with distance from field sites. CONCLUSIONS: The association between residential proximity to organochlorine pesticide applications during gestation and ASD among children should be further studied. pubtype: Academic Journal doctype: research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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