Long-term continuous glucose monitoring with microdialysis in ambulatory insulin-dependent diabetic patients.
The glucose concentration in the extracellular space of subcutaneous adipose tissue closely mirrors the blood glucose concentration. With a microdialysis technique, we undertook continuous ambulatory monitoring of adipose tissue glucose in 17 insulin-dependent diabetic patients with labile glycaemic...
| Publicado en: | Lancet Vol. 342; no. 8879; pp. 1080 - 1086 |
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| Autores principales: | , , , , , |
| Formato: | research Journal Article |
| Publicado: |
Lancet
10/30/1993
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=105851507&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 105851507 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 01406736 LAN jtl: Lancet issn: 01406736 maglogo: N pubinfo: dt: 10/30/1993 vid: 342 iid: 8879 pid: 1297 pub: Lancet place: Philadelphia, Pennsylvania artinfo: ui: 105851507 105851507 NLM8105311 2009848283 10.1016/0140-6736(93)92063-y NLM8105311 105851507 ppf: 1080 ppct: 6 formats: fmt: @attributes: type: T tig: atl: Long-term continuous glucose monitoring with microdialysis in ambulatory insulin-dependent diabetic patients. aug: au: Bolinder, Jan Ungcrstedt, Urban Amer, Peter Bolinder, J Ungerstedt, U Arner, P affil: Department of Medicine and the Research Centre, Huddinge Hospital and Department of Pharmacology, Karollnska Institute, Stockholm, Sweden (J Bolinder MD, U Ungerstedt MD, P Arner MD) sug: subj: Adipose Tissue Metabolism Diabetes Mellitus, Type 1 Metabolism Dialysis Equipment and Supplies Glucose Analysis Adult Ambulatory Care Diabetes Mellitus, Type 1 Drug Therapy Female Infusion Pumps Insulin Administration and Dosage Male Middle Age Monitoring, Physiologic Equipment and Supplies Adult: 19-44 years Middle Aged: 45-64 years Female Male ab: The glucose concentration in the extracellular space of subcutaneous adipose tissue closely mirrors the blood glucose concentration. With a microdialysis technique, we undertook continuous ambulatory monitoring of adipose tissue glucose in 17 insulin-dependent diabetic patients with labile glycaemic control. The aims of the study were to investigate performance of the microdialysis device and to evaluate whether consecutive 24 h glucose profiles could be used to adjust insulin therapy. A microdialysis probe was implanted subcutaneously, perfused by a portable microinfusion pump, and dialysate fractions were collected every 1 or 2 h for 75 h. The mean (SE) tissue dialysate glucose concentration was 93 (3)% of the concentration in venous plasma, and variations in adipose tissue glucose closely paralleled changes in plasma glucose. Mean 24 h tissue glucose concentration correlated significantly with glycosylated haemoglobin (HbA1c; r = 0.62, p < 0.01). Most patients had a reproducible daily pattern of glucose swings, and in more than half the patients consecutive ambulatory glucose profiles were almost superimposed. When patients' insulin therapy was adjusted on the basis of ambulatory glucose monitoring, HbA1c decreased by almost 2% (p < 0.01), and this decrease lasted for at least 9 months. Microdialysis of adipose tissue can be used for continuous long-term monitoring of glucose concentrations in diabetic patients during ordinary daily life. Daily glucose profiles are often reproducible and the recordings may thus be used for individual tailoring of insulin therapy to improve glycaemic control. pubtype: Academic Journal doctype: research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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