Nasal cytokine production in viral acute upper respiratory infection of childhood.
Children in a day care center underwent serial nasal lavages in order to assess nasal cytokine expression during acute upper respiratory infections (URI). Interleukin (IL)-1 beta, IL-8, IL-6, and tumor necrosis factor-alpha (TNF-alpha) were markedly elevated in nasal lavage fluid during acute URI co...
| Publicado en: | Journal of Infectious Diseases Vol. 171; no. 3; pp. 584 - 593 |
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| Autores principales: | , , , , , , , , , , , , , |
| Formato: | research Journal Article |
| Publicado: |
Oxford University Press / USA
1995 Mar
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=105854431&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 105854431 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 00221899 1YU jtl: Journal of Infectious Diseases issn: 00221899 maglogo: N pubinfo: dt: 1995 Mar vid: 171 iid: 3 pid: 622 pub: Oxford University Press / USA artinfo: ui: 105854431 105854431 NLM7876605 2009847593 NLM7876605 105854431 ppf: 584 ppct: 9 formats: tig: atl: Nasal cytokine production in viral acute upper respiratory infection of childhood. aug: au: Noah TL Henderson FW Wortman IA Devlin RB Handy J Koren HS Becker S Noah, T L Henderson, F W Wortman, I A Devlin, R B Handy, J Koren, H S Becker, S affil: Department of Pediatrics, University of North Carolina at Chapel Hill 27599-7220 sug: subj: Cytokines Nose Metabolism Respiratory Tract Infections Immunology Acute Disease Child, Preschool Documentation Infant Interleukins Nucleotides Polymerase Chain Reaction RNA Analysis Tumor Necrosis Factor Child, Preschool: 2-5 years Infant: 1-23 months ab: Children in a day care center underwent serial nasal lavages in order to assess nasal cytokine expression during acute upper respiratory infections (URI). Interleukin (IL)-1 beta, IL-8, IL-6, and tumor necrosis factor-alpha (TNF-alpha) were markedly elevated in nasal lavage fluid during acute URI compared to baseline, and all except TNF-alpha decreased significantly by 2-4 weeks later. Cytokine patterns in respiratory syncytial virus-positive and -negative illnesses did not differ significantly. A subgroup of children also underwent superficial mucosal biopsy under the inferior nasal turbinate. During acute URI, biopsy cells (90%-95% epithelial) showed increased transcripts for IL-1 beta, IL-8, and IL-6 in 7 of 9 subjects, suggesting that epithelial cells may be one source of cytokines during acute URI. The results show that inflammatory cytokines are elevated in nasal secretions during acute URI in preschool children. Thus, cytokines are likely to participate in regulation of respiratory virus-induced inflammation. pubtype: Academic Journal doctype: research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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