Computer-simulated alternative modes of U-wave genesis.
OBJECTIVE: Several hypotheses for the origin of the U wave in electrocardiograms have been proposed. We have set out to explore and test alternative modes for U-wave genesis via computer simulations. METHODS AND RESULTS: A spatial model of a left ventricle has been constructed from 12 layers compose...
| Publicado en: | Journal of Cardiovascular Electrophysiology Vol. 19; no. 1; pp. 84 - 90 |
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| Autores principales: | , , |
| Formato: | research Journal Article |
| Publicado: |
Wiley-Blackwell
Jan2008
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=105862089&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 105862089 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 10453873 GSB jtl: Journal of Cardiovascular Electrophysiology issn: 10453873 maglogo: Y pubinfo: dt: Jan2008 vid: 19 iid: 1 pid: 480 pub: Wiley-Blackwell place: Malden, Massachusetts artinfo: ui: 105862089 105862089 2009753852 10.1111/j.1540-8167.2007.00978.x NLM17916148 105862089 ppf: 84 ppct: 6 formats: fmt: @attributes: type: P tig: atl: Computer-simulated alternative modes of U-wave genesis. aug: au: Depolli M Avbelj V Trobec R affil: Department of Communication Systems, Jozef Stefan Institute, Ljubljana, Slovenia. matjaz.depolli@ijs.si sug: subj: Action Potentials Physiology Cell Physiology Electrocardiography Methods Heart Conduction System Physiology Heart Ventricle Physiology Models, Biological Animals Computer Simulation Animal Studies ab: OBJECTIVE: Several hypotheses for the origin of the U wave in electrocardiograms have been proposed. We have set out to explore and test alternative modes for U-wave genesis via computer simulations. METHODS AND RESULTS: A spatial model of a left ventricle has been constructed from 12 layers composed of cubic cells. Each cell is assigned its own time-dependent action potential with its own contribution to the electrical potential at arbitrary points where ECGs are measured. Simulated ECGs show that U waves can be generated using various combinations of action potentials (APs) across the different layers of the ventricular wall. We demonstrate a new mode of U-wave genesis, even with small differences in the repolarization. CONCLUSION: The U wave can be generated in the presence of strong intercellular coupling. Myocardial layers with prolonged action potentials, like M cells, are not necessarily needed for U-wave genesis. pubtype: Academic Journal doctype: research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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