Neural substrate differences in language networks and associated language-related behavioral impairments in children with TBI: A preliminary fMRI investigation.
The present study examined whether functional MRI (fMRI) can identify changes in the neural substrates of language in young children following traumatic brain injury (TBI). Eight children with TBI (F/M=3/5, age (Mean ± SD)=7.98 ± 1 years, range = 6-9 years) and a comparison group of nine children wi...
| Published in: | NeuroRehabilitation Vol. 22; no. 5; pp. 355 - 370 |
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| Main Authors: | , , , , , , |
| Format: | clinical trial research Journal Article |
| Published: |
Sage Publications Inc.
2007
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| Online Access: | View this record in EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=105893505&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 105893505 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 10538135 3RE jtl: NeuroRehabilitation issn: 10538135 maglogo: N pubinfo: dt: 2007 vid: 22 iid: 5 pid: 344 pub: Sage Publications Inc. place: Thousand Oaks, California artinfo: ui: 105893505 105893505 2009753394 10.3233/nre-2007-22503 NLM18162699 105893505 ppf: 355 ppct: 15 formats: fmt: @attributes: type: P tig: atl: Neural substrate differences in language networks and associated language-related behavioral impairments in children with TBI: A preliminary fMRI investigation. aug: au: Karunanayaka PR Holland SK Altaye M Jones BV Michaud LJ Walz NC Wade SL affil: Pediatric Neuroimaging Research Consortium, Imaging Research Center, Department of Radiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA sug: subj: Brain Injuries Pathology Brain Injuries Psychosocial Factors Language Magnetic Resonance Imaging Brain Injuries Physiopathology Child Clinical Trials Female Glasgow Coma Scale Language Tests Male Neuropsychological Tests Pilot Studies Readability Speech Physiology Task Performance and Analysis Human Child: 6-12 years Female Male ab: The present study examined whether functional MRI (fMRI) can identify changes in the neural substrates of language in young children following traumatic brain injury (TBI). Eight children with TBI (F/M=3/5, age (Mean ± SD)=7.98 ± 1 years, range = 6-9 years) and a comparison group of nine children with orthopedic injuries (OI) (F/M=4/5, age (Mean ± SD)=7.4 ± 1 years, range=6-9 years) participated in an fMRI study of covert verb generation (VG). Results revealed significantly different BOLD signal activation in perisylvian language areas between the groups, after accounting for potential confounders such as verbal fluency and executive function. We also found significant associations between the BOLD signal activation and performance on language-specific neuropsychological tests (NEPSY verbal fluency score, Verbal IQ) and Glasgow Coma Scale (GCS) score. This study suggests that children with TBI have significantly different brain activation patterns in language circuitry compared to children with orthopedic injuries. Although we found clear differences in brain activation between the two groups, conventional MR images showed no evidence of structural abnormalities in five of eight children with TBI. Our study demonstrates the feasibility and potential utility of fMRI as a means of quantifying changes associated with language deficits in future pediatric TBI studies. pubtype: Academic Journal doctype: clinical trial research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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