Hemichorea associated with gabapentin therapy with hypoperfusion in contralateral basal ganglion -- a case of a paraplegic patient with neuropathic pain.
Functional imaging in patients with movement disorders has suggested abnormalities of regional cerebral blood flow (rCBF). We describe a patient with thoracic cord lesion with subsequent severe neuropathic pain. Right hemichorea developed and was related to adjunctive therapy with gabapentin. The pa...
| Publicado en: | Journal of Clinical Pharmacy & Therapeutics Vol. 33; no. 1; pp. 83 - 87 |
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| Autores principales: | , , , , |
| Formato: | case study Journal Article |
| Publicado: |
Wiley-Blackwell
Feb2008
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=105894919&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 105894919 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 02694727 EV4 jtl: Journal of Clinical Pharmacy & Therapeutics issn: 02694727 maglogo: Y pubinfo: dt: Feb2008 vid: 33 iid: 1 pid: 480 pub: Wiley-Blackwell place: Malden, Massachusetts artinfo: ui: 105894919 105894919 2009770867 10.1111/j.1365-2710.2008.00882.x NLM18211622 105894919 ppf: 83 ppct: 4 formats: fmt: @attributes: type: P tig: atl: Hemichorea associated with gabapentin therapy with hypoperfusion in contralateral basal ganglion -- a case of a paraplegic patient with neuropathic pain. aug: au: Lai M Wang T Chang C Tsai K Chang S sug: subj: Acids, Carbocyclic Adverse Effects Amines Adverse Effects Analgesics Adverse Effects Basal Ganglia Drug Effects Chorea Chemically Induced GABA Adverse Effects Neuralgia Drug Therapy Adult Basal Ganglia Blood Supply Cerebrovascular Circulation Drug Effects Male Paraplegia Tomography, Emission-Computed, Single-Photon Adult: 19-44 years Male ab: Functional imaging in patients with movement disorders has suggested abnormalities of regional cerebral blood flow (rCBF). We describe a patient with thoracic cord lesion with subsequent severe neuropathic pain. Right hemichorea developed and was related to adjunctive therapy with gabapentin. The patient's hemichorea decreased gradually after cessation of gabapentin. The study of rCBF revealed hypoperfusion in the contralateral basal ganglia compared with the previous study of rCBF. Our patient is the first patient with neuropathic pain, treated with gabapentin who developed hemichorea, in the absence of brain lesions. Imaging studies of rCBF showed a perfusion defect in the contralateral basal ganglion. pubtype: Academic Journal doctype: case study Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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