Claims in advertisements for antihypertensive drugs in a Dutch medical journal.
BACKGROUND: Advertising claims must not conflict with the official summary of product characteristics. After a drug has been approved, new clinical evidence may become available. AIMS: To determine how the pharmaceutical industry deals with evolving clinical evidence in advertising claims for antihy...
| Publicado en: | Journal of Hypertension Vol. 25; no. 3; pp. 713 - 723 |
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| Autores principales: | , , , |
| Formato: | research Journal Article |
| Publicado: |
Lippincott Williams & Wilkins
2007 Mar
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=105926038&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 105926038 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 02636352 IQF jtl: Journal of Hypertension issn: 02636352 maglogo: N pubinfo: dt: 2007 Mar vid: 25 iid: 3 pid: 433 pub: Lippincott Williams & Wilkins place: Baltimore, Maryland artinfo: ui: 105926038 105926038 2009510659 10.1097/hjh.0b013e328012662a NLM17278989 105926038 ppf: 713 ppct: 10 formats: tig: atl: Claims in advertisements for antihypertensive drugs in a Dutch medical journal. aug: au: Greving JP Denig P de Zeeuq D Haaijer-Ruskamp FM sug: subj: Advertising Ethical Issues Antihypertensive Agents Industry Ethical Issues Medical Practice, Evidence-Based Netherlands Peer Review Publishing Reproducibility of Results Truth Disclosure Human ab: BACKGROUND: Advertising claims must not conflict with the official summary of product characteristics. After a drug has been approved, new clinical evidence may become available. AIMS: To determine how the pharmaceutical industry deals with evolving clinical evidence in advertising claims for antihypertensive drugs, and whether such pharmaceutical promotion is up to standard. METHODS: We examined all advertisements from the Dutch Journal of Medicine published between 1996 and 2004. We judged whether claims were in agreement with the information available from the summary of product characteristics or evidence from cited clinical trials. Subsequently, we reviewed whether these claims had been assessed by the Code of Practice authority. RESULTS: We identified 50 unique advertisements with, in total, 492 appearances for 16 antihypertensive drugs. Claims of blood pressure lowering and convenient use were all judged to be sufficiently substantiated. For calcium-channel blockers, insufficiently supported safety claims had been made in three cases (41 appearances). Claims suggesting effects on long-term outcomes started in 1999 for angiotensin II receptor blockers, and were made during the whole period for several other antihypertensive drugs. In 16 cases (135 appearances), such claims were not supported by the available information. Some claims were premature, others transferred results from a specific patient group to the general population of hypertensive patients. Only two cases were reviewed by the Code of Practice authority. CONCLUSIONS: Overall, 35% of the advertisements for antihypertensive drugs contained suggestive claims not supported by the offered evidence. The current system of self-regulation cannot ensure that pharmaceutical promotion is always accurate, balanced and evidence-based. pubtype: Academic Journal doctype: research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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