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Profile of drug interactions in hospitalized children.

Introduction: The expected therapeutic response may be affected by the presence of drug interactions. With the high number of reports on new drug interactions, it has been difficult for health professionals to keep constantly updated. For this reason, computer systems have helped identify such inter...

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Published in:Pharmacy Practice (1886-3655) Vol. 5; no. 4; pp. 157 - 162
Main Authors: Martinbiancho J, Zuckermrann J, Dos Santos L, Silva MM
Format: research tables/charts Journal Article
Published: Centro de Investigaciones y Publicaciones Farmaceuticas S.L. Nov2007
Online Access:View this record in EBSCOhost
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      pub: Centro de Investigaciones y Publicaciones Farmaceuticas S.L.
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        atl: Profile of drug interactions in hospitalized children.
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        au:
          Martinbiancho J
          Zuckermrann J
          Dos Santos L
          Silva MM
        affil: Pharmacist, Pharmacy Service, Hospital de Clínicas de Porto Alegre-RS, Brazil
      sug:
        subj:
          Child, Hospitalized
          Drug Interactions Evaluation
          Academic Medical Centers
          Adverse Drug Event Epidemiology
          Brazil
          Child
          Child, Preschool
          Descriptive Research
          Drug Incompatibility
          Drug Therapy, Combination
          Funding Source
          Infant
          Infant, Newborn
          Polypharmacy Adverse Effects
          Prescriptions, Drug
          Human
          Child: 6-12 years
          Child, Preschool: 2-5 years
          Infant: 1-23 months
          Infant, Newborn: birth-1 month
      ab:
        Introduction: The expected therapeutic response may be affected by the presence of drug interactions. With the high number of reports on new drug interactions, it has been difficult for health professionals to keep constantly updated. For this reason, computer systems have helped identify such interactions. Objectives: To verify the rate and profile of drug interactions in medical prescriptions to hospitalized pediatric patients. Methods: A descriptive study investigated prescriptions to hospitalized pediatric patients. The study included patients between 0 and 12 years old, containing 4 or more drugs in their prescriptions. The analysis of interaction and incompatibility possibilities in prescribed drugs used Micromedex / Drug-Reax® program. Results: From 2005 to 2006, 3,170 patients were investigated, and 11,181 prescriptions were analyzed, a mean value of 3.5 prescriptions/patient. In total, 6,857 drug interactions were found, which corresponds to 1.9 interaction/prescription. Among them, relevance to ampicillin and gentamicin, found in 220 (3.2%) prescriptions. In total, 2,411 drug incompatibilities in via y were found, a mean value of 0.5/prescription, with emphasis on vancomycin and cefepime, found in 243 (10.0%) prescriptions. Conclusion: The presence of drug interactions is a permanent risk in hospitals. This way, the utilization of computer programs, pharmacotherapy monitoring of patients and the pharmacist presence in the multidisciplinary team are some manners of contributing to hospitalized patients' treatment.
        Introducción: La respuesta terapéutica esperada puede modificarse por la presencia de interacciones medicamentosas. Con el elevado número de comunicaciones de nuevas interacciones medicamentosas, ha sido difícil para los profesionales de la salud mantenerse constantemente actualizados. Por este motivo, los ordenadores han ayudado a identificar estas interacciones. Objetivos: Verificar la tasa y el perfil de las interacciones medicamentosas en las prescripciones médicas a pacientes pediátricos hospitalizados. Métodos: Un estudio descriptivo investigó las prescripciones a pacientes pediátricos hospitalizados. El estudio incluyó pacientes entre 0 y 12 años, que tenían 4 o más medicamentos en sus prescripciones. El análisis de las interacciones y las incompatibilidades posibles en los medicamentos prescritos utilizó el programa Micromedex / Drug-Reax(r). Resultados: De 2005 a 2006, se investigó a 3.170 pacientes y se analizaron 11.181 prescripciones con una media de 3,5 recetas/paciente. En total se encontraron 6.857 interacciones medicamentosas, que corresponden a 1,9 interacciones/prescripción. Entre ellas, se encontró relación a ampicilina y gentamicina en 220 (3,2%). En total, se encontraron 2.411 incompatibilidades de vía, con una media de 0,5 por prescripción, con énfasis en vancomicina y cefepime, encontradas en 243 (10,0%). Conclusión: La presencia de interacciones medicamentosas es un riesgo permanente en hospitales. Así que, la utilización de un programa informático, el seguimiento farmacoterapéutico de los pacientes y la presencia de un farmacéutico en el equipo multidisciplinario son algunas de las maneras de mejorar el tratamiento de los pacientes hospitalizados.
      pubtype: Academic Journal
      doctype:
        research
        tables/charts
        Journal Article
      ougenre: Article
    language: English
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