Lipopolysaccharide-binding protein in noninfected neonates and those with suspected early-onset bacterial infection.
OBJECTIVES: To investigate postnatal lipopolysaccharide-binding protein (LBP) kinetics in term neonates and to test its diagnostic accuracy for early-onset bacterial infection (EOBI). STUDY DESIGN: A total of 99 neonates with clinical and serological signs of EOBI comprised the study group; 198 neon...
| Publicado en: | Journal of Perinatology Vol. 26; no. 2; pp. 115 - 120 |
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| Autores principales: | , , , , , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
Springer Nature
Feb2006
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=105934798&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 105934798 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 07438346 DZF jtl: Journal of Perinatology issn: 07438346 maglogo: Y pubinfo: dt: Feb2006 vid: 26 iid: 2 pid: 2579 pub: Springer Nature place: Dordrecht, <Blank> artinfo: ui: 105934798 105934798 2009328173 10.1038/sj.jp.7211422 NLM16407966 105934798 ppf: 115 ppct: 5 formats: fmt: @attributes: type: P tig: atl: Lipopolysaccharide-binding protein in noninfected neonates and those with suspected early-onset bacterial infection. aug: au: Orlikowsky TW Trüg C Neunhoeffer F Deperschmidt M Eichner M Poets CF sug: subj: Lipopolysaccharide-Binding Protein Metabolism Bacterial Infections Diagnosis C-Reactive Protein Metabolism Interleukins Metabolism Bacterial Infections Microbiology Biological Markers Analysis C-Reactive Protein Analysis Lipopolysaccharide-Binding Protein Analysis Case Control Studies Confidence Intervals Female Infant, Newborn Interleukins Analysis Male Predictive Value of Tests Probability Prospective Studies Reference Values Risk Assessment ROC Curve Sensitivity and Specificity Severity of Illness Indices Human Infant, Newborn: birth-1 month Female Male ab: OBJECTIVES: To investigate postnatal lipopolysaccharide-binding protein (LBP) kinetics in term neonates and to test its diagnostic accuracy for early-onset bacterial infection (EOBI). STUDY DESIGN: A total of 99 neonates with clinical and serological signs of EOBI comprised the study group; 198 neonates with risk factors, but without EOBI, served as controls. LBP, C-reactive protein (CRP) and interleukin-8 (IL-8) were determined. RESULTS: LBP in the noninfected group increased until 24 h after birth (P < 0.05 vs 6 h). LBP and CRP correlated strongly in neonates with suspected EOBI (r = 0.63). Although LBP reached a higher sensitivity than CRP 6 and 12 h after clinical suspicion (45 (24-68) and 79% (54-94) vs 9 (0-24) and 39% (17-64); P < 0.05)), EOBI was most reliably detected by IL-8. CONCLUSION:LBP kinetics were age-dependent. LBP was not sufficiently sensitive in the prediction of EOBI. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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