Learning disabilities in children with neurofibromatosis type 1: subtypes, cognitive profile, and attention-deficit-hyperactivity disorder.

Cognitive deficits are the most common complication in children with neurofibromatosis type 1 (NF1), and academic achievement is broadly affected. There is a lack of consensus in the literature regarding the frequency of general and specific learning disabilities, which seems to be related to the la...

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Publicado en:Developmental Medicine & Child Neurology Vol. 48; no. 12; pp. 973 - 978
Autores principales: Hyman SL, Arthur Shores E, North KN
Formato: research Journal Article
Publicado: Wiley-Blackwell Dec2006
Acceso en línea:Ver este registro en EBSCOhost
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      dt: Dec2006
      vid: 48
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      pub: Wiley-Blackwell
      place: Malden, Massachusetts
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        atl: Learning disabilities in children with neurofibromatosis type 1: subtypes, cognitive profile, and attention-deficit-hyperactivity disorder.
      aug:
        au:
          Hyman SL
          Arthur Shores E
          North KN
      sug:
        subj:
          Attention Deficit Hyperactivity Disorder Epidemiology
          Cognition Disorders Epidemiology
          Intelligence
          Learning Disorders Epidemiology
          Neurofibromatosis 1 Psychosocial Factors
          Adolescence
          Case Control Studies
          Child
          Educational Status
          Female
          Male
          Prospective Studies
          Psychological Tests
          Human
          Adolescent: 13-18 years
          Child: 6-12 years
          Female
          Male
      ab: Cognitive deficits are the most common complication in children with neurofibromatosis type 1 (NF1), and academic achievement is broadly affected. There is a lack of consensus in the literature regarding the frequency of general and specific learning disabilities, which seems to be related to the lack of a consensus on diagnostic criteria. The present study examined the frequency of specific learning disabilities (SLDs) in NF1, using an intellect-achievement discrepancy for diagnosis, as well as general learning difficulty associated with a lowering of general intellectual ability. The cohort consisted of 81 children with NF1 (43 males, 38 females; mean age 11y 6mo [SD 2y 4mo]; range 8y-16y 9mo) and 49 comparison children (20 males, 29 females; mean age 12y [SD 2y 6mo]; range 8y 2mo-16y 8mo). Problems with academic achievement were present in 52% of children with NF1; however, only 20% of the children with NF1 were diagnosed with an SLD (32% had more general learning problems). Only males with NF1 were at significant risk for SLD, and Verbal IQ<Performance IQ discrepancies were predictive of the presence of an SLD. There was a significant comorbidity of literacy-based learning disabilities and attention-deficit-hyperactivity disorder. We were able to define three subtypes of children with NF1 having distinct cognitive profiles, each with important implications for assessment and remediation.
      pubtype: Academic Journal
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        Journal Article
      ougenre: Article
    language: English
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