Single dose pharmacokinetic study of lithium in Taiwanese/Chinese bipolar patients.
OBJECTIVE: The purpose of this study is to investigate the single dose pharmacokinetics of lithium in Taiwanese/Chinese bipolar patients for future interracial comparisons. METHOD: Eight bipolar patients took 900 mg of lithium carbonate after overnight fasting. Blood samples of 5 mL were taken after...
| Publicado en: | Australian & New Zealand Journal of Psychiatry Vol. 32; no. 1; pp. 133 - 137 |
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| Autores principales: | , , |
| Formato: | research Journal Article |
| Publicado: |
Sage Publications Inc.
Feb1998
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=105973040&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 105973040 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 00048674 7ZU jtl: Australian & New Zealand Journal of Psychiatry issn: 00048674 maglogo: Y pubinfo: dt: Feb1998 vid: 32 iid: 1 pid: 344 pub: Sage Publications Inc. place: Thousand Oaks, California artinfo: ui: 105973040 105973040 2009780983 10.3109/00048679809062720 NLM9565195 105973040 ppf: 133 ppct: 4 formats: fmt: @attributes: type: P tig: atl: Single dose pharmacokinetic study of lithium in Taiwanese/Chinese bipolar patients. aug: au: Lee CF Yang YY Hu OY sug: subj: Bipolar Disorder Blood Ethnic Groups Psychosocial Factors Ethnological Research Lithium Carbonate Pharmacokinetics Adolescence Adult Bipolar Disorder Drug Therapy Bipolar Disorder Ethnology Female Lithium Carbonate Adverse Effects Lithium Carbonate Therapeutic Use Male Metabolic Clearance Rate Reference Values Taiwan Time Human Adolescent: 13-18 years Adult: 19-44 years Female Male ab: OBJECTIVE: The purpose of this study is to investigate the single dose pharmacokinetics of lithium in Taiwanese/Chinese bipolar patients for future interracial comparisons. METHOD: Eight bipolar patients took 900 mg of lithium carbonate after overnight fasting. Blood samples of 5 mL were taken after 15 min, 30 min, 45 min, 1 h, 2 h, 3 h, 4 h, 7 h, 9 h, 15 h, 25 h and 31 h after dosing. The computer programs CSTRIP and PCNONLIN were used for pharmacokinetic analysis. RESULTS: The pharmacokinetic parameters obtained were as follows: Cmax, 0.970 +/- 0.170 (SD) mmol/L; Tmax, 1.59 +/- 0.78 h; AUC31 h = 548.9 +/- 135.4 mmol x m/L; AUC to infinity = 722.6 +/- 262.7 mmol x m/L; beta-half-life = 16.3 +/- 7.18 h; kappa-half-life = 0.613 +/- 0.442 h; Cl(oral) = 1.13 +/- 0.39 mL/min/kg; Vd/F = 1.43 +/- 0.387 L/kg. Most of the pharmacokinetic parameters were within the ranges reported in investigations of Caucasian subjects. CONCLUSIONS: This study showed that racial differences in lithium pharmacokinetics might not exist. We suggest that methodological designs, including method of blood sampling, measurement of lithium, and pharmacokinetic and statistical calculations, be standardised if future cross-ethnic comparisons are to be conducted. pubtype: Academic Journal doctype: research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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