Gastric alpha-tocopherol and beta-carotene concentrations in association with Helicobacter pylori infection.
Objective: The effects of Helicobacter pylori infection and its associated gastric histology on alpha-tocopherol and beta-carotene concentrations in serum, gastric juice and antral mucosa were investigated in patients undergoing routine gastroscopy for investigation of dyspepsia.Method: Eighty-six p...
| Publicado en: | European Journal of Gastroenterology & Hepatology Vol. 12; no. 5; pp. 497 - 504 |
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| Autores principales: | , , , , , , , , , |
| Formato: | research Journal Article |
| Publicado: |
Lippincott Williams & Wilkins
2000 May
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=105974565&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 105974565 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 0954691X 8CE jtl: European Journal of Gastroenterology & Hepatology issn: 0954691X maglogo: N pubinfo: dt: 2000 May vid: 12 iid: 5 pid: 5086 pub: Lippincott Williams & Wilkins place: Baltimore, Maryland artinfo: ui: 105974565 105974565 NLM10833091 2009784297 10.1097/00042737-200012050-00004 NLM10833091 105974565 ppf: 497 ppct: 7 formats: tig: atl: Gastric alpha-tocopherol and beta-carotene concentrations in association with Helicobacter pylori infection. aug: au: Zhang ZW Patchett SE Perrett D Domizio P Farthing MJ Zhang, Z W Patchett, S E Perrett, D Domizio, P Farthing, M J affil: Digestive Diseases Research Centre, St Bartholomew's and the Royal and London School of Medicine and Dentistry, London, UK sug: subj: beta Carotene Metabolism Helicobacter Infections Metabolism Helicobacter Pylori Vitamin E Metabolism Adult Aged Aged, 80 and Over Alcohol Drinking Analysis of Variance Chromatography, High Pressure Liquid Female Gastroscopy Helicobacter Infections Pathology Male Middle Age Nonparametric Statistics Human Adult: 19-44 years Aged: 65+ years Aged, 80 & over Middle Aged: 45-64 years Female Male ab: Objective: The effects of Helicobacter pylori infection and its associated gastric histology on alpha-tocopherol and beta-carotene concentrations in serum, gastric juice and antral mucosa were investigated in patients undergoing routine gastroscopy for investigation of dyspepsia.Method: Eighty-six patients were studied. High-performance liquid chromatography was used to measure alpha-tocopherol and beta-carotene concentrations. H. pylori infection was assessed by histology, bacterial culture, rapid urease test and serology.Results: No obvious association was found between age, sex, smoking or endoscopic diagnosis and alpha-tocopherol or beta-carotene concentrations in serum, gastric juice and antral mucosa. However, alcohol drinkers had significantly lower antral mucosal and gastric juice beta-carotene concentrations compared to non-drinkers. Gastric juice beta-carotene concentration was markedly lower in patients infected with H. pylori than uninfected controls (2.9 nmol/l (interquartile range 0.3-4.3) versus 4.6 nmol/l (interquartile range 3.5-7.6), P = 0.01), but there was no significant difference in serum or gastric mucosal beta-carotene concentrations between the two patient groups. The presence of gastric atrophy and intestinal metaplasia was significantly associated with reduced mucosal alpha-tocopherol and beta-carotene concentrations. Furthermore, antral mucosal alpha-tocopherol concentrations decreased progressively as antral mucosal histology changed from normal to chronic gastritis alone and finally to atrophy and intestinal metaplasia.Conclusion: Gastric alpha-tocopherol and beta-carotene concentrations are affected by H. pylori-associated gastric histological changes, and these findings suggest that H. pylori infection may not only impair the protective role of vitamin C, but also of alpha-tocopherol and beta-carotene in the stomach. pubtype: Academic Journal doctype: research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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