Non-Helicobacter pylori and non-NSAID peptic ulcer disease in the Japanese population.
Background: Helicobacter pylori and non-steroidal anti-inflammatory drugs (NSAIDs) are recognized as the major causes of peptic ulcer disease. The status of H. pylori infection in the background population may influence the incidence of H. pylori-negative peptic ulcer disease.Objective: To examine t...
| Publicado en: | European Journal of Gastroenterology & Hepatology Vol. 12; no. 6; pp. 635 - 641 |
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| Autores principales: | , , , , , , , , , , , , , , , , , , , |
| Formato: | research Journal Article |
| Publicado: |
Lippincott Williams & Wilkins
2000 Jun
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=105974591&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 105974591 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 0954691X 8CE jtl: European Journal of Gastroenterology & Hepatology issn: 0954691X maglogo: N pubinfo: dt: 2000 Jun vid: 12 iid: 6 pid: 5086 pub: Lippincott Williams & Wilkins place: Baltimore, Maryland artinfo: ui: 105974591 105974591 NLM10912481 2009784462 10.1097/00042737-200012060-00010 NLM10912481 105974591 ppf: 635 ppct: 6 formats: tig: atl: Non-Helicobacter pylori and non-NSAID peptic ulcer disease in the Japanese population. aug: au: Nishikawa K Sugiyama T Kato M Ishizuka J Komatsu Y Kagaya H Katagiri M Nishikawa S Hokari K Takeda H Asaka M Nishikawa, K Sugiyama, T Kato, M Ishizuka, J Komatsu, Y Kagaya, H Katagiri, M Nishikawa, S Hokari, K affil: Third Department of Internal Medicine, Hokkaido University School of Medicine, Sapporo, Japan sug: subj: Antiinflammatory Agents, Non-Steroidal Adverse Effects Helicobacter Infections Epidemiology Helicobacter Pylori Peptic Ulcer Epidemiology Adult Female Gastric Mucosa Pathology Helicobacter Infections Diagnosis Helicobacter Infections Pathology Japan Male Middle Age Peptic Ulcer Chemically Induced Peptic Ulcer Microbiology Peptic Ulcer Pathology Risk Factors Human Adult: 19-44 years Middle Aged: 45-64 years Female Male ab: Background: Helicobacter pylori and non-steroidal anti-inflammatory drugs (NSAIDs) are recognized as the major causes of peptic ulcer disease. The status of H. pylori infection in the background population may influence the incidence of H. pylori-negative peptic ulcer disease.Objective: To examine the incidence of H. pylori-negative peptic ulcer disease without intake of NSAIDs in Japan.Patients: A total of 398 patients who had no eradication therapy for H. pylori prior to this study, including 246 patients with gastric ulcer (GU) and 152 patients with duodenal ulcer (DU), were enrolled.Methods: H. pylori status was assessed by rapid urease tests, histological examinations (haematoxylin & eosin stain, Giemsa stain and/or immunostaining) and serum IgG antibody. Two biopsy specimens were taken from the antrum within 3 cm of the pyloric and two from the middle corpus of the stomach, along the greater curvature. Patients were asked a series of questions regarding risk factors, including the use of NSAIDs. The presence of gastritis, gastric atrophy and intestinal metaplasia was examined according to the updated Sydney system.Results: Of the 246 patients with GU, 12 patients (4.9%) were considered to be H. pylori-negative. Of the 152 patients with DU, two patients (1.3%) were considered to be H. pylori-negative. Hence, a total of 14 patients were found to be H. pylori-negative. Nine of them were taking NSAIDs. Consequently, the frequency of H. pylori-negative ulcer without intake of NSAIDs was 1.3%. There was no significant difference in the frequencies of H. pylori-negative patients between the GU and DU groups.Conclusion: The incidence of H. pylori-negative peptic ulcer disease without intake of NSAIDs was very low in the Japanese population. pubtype: Academic Journal doctype: research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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