Design and delivery of non-parenteral vaccines.
Non-parenteral delivery of vaccines is reviewed focusing on the delivery systems that have been used for various mucosal routes of administration. Systems considered include biodegradable micro- and nanoparticles, liposomes, live bacterial and viral vectors and mucosal adjuvants. New approaches to m...
| Publicado en: | Journal of Clinical Pharmacy & Therapeutics Vol. 23; no. 4; pp. 257 - 286 |
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| Autores principales: | , , |
| Formato: | Journal Article |
| Publicado: |
Wiley-Blackwell
Aug98
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=105975004&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 105975004 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 02694727 EV4 jtl: Journal of Clinical Pharmacy & Therapeutics issn: 02694727 maglogo: Y pubinfo: dt: Aug98 vid: 23 iid: 4 pid: 480 pub: Wiley-Blackwell place: Malden, Massachusetts artinfo: ui: 105975004 2009782228 NLM9867311 105975004 ppf: 257 ppct: 29 formats: fmt: @attributes: type: P tig: atl: Design and delivery of non-parenteral vaccines. aug: au: Nugent J Po AL Scott EM sug: subj: Drug Delivery Systems Drug Design Vaccines Administration and Dosage Animals Antigens Metabolism Antigens Physiology Chemistry, Pharmaceutical Cytokines Physiology Immunity Immunoglobulins Physiology T Lymphocytes Physiology ab: Non-parenteral delivery of vaccines is reviewed focusing on the delivery systems that have been used for various mucosal routes of administration. Systems considered include biodegradable micro- and nanoparticles, liposomes, live bacterial and viral vectors and mucosal adjuvants. New approaches to mucosal vaccine formulation using: (i) gene fusion technology to create non-toxic derivatives of mucosal adjuvants, (ii) genetically inactivated antigens with a deletion in an essential gene, (iii) coexpression of an antigen and a specific cytokine that is important in the modulation and control of a mucosal immune response, and (iv) genetic material itself that would allow DNA or RNA uptake and its endogenous expression in the host cell are described. pubtype: Academic Journal doctype: Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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