Population-based investigations of drug relative clearance using nonlinear mixed-effect modelling from information generated during the routine clinical care of patients.
Interpatient variability in drug disposition and response is a therapeutic premise, and thus evaluation and management of such variability are the basis for individualized pharmacotherapy. If the mathematical approach to determining drug doses were accurate and practical, the use of calculated doses...
| Publicado en: | Journal of Clinical Pharmacy & Therapeutics Vol. 24; no. 2; pp. 103 - 114 |
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| Autor principal: | |
| Formato: | Journal Article |
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Wiley-Blackwell
Apr99
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| Acceso en línea: | Ver este registro en EBSCOhost |