Biologic models of traumatic memories and post-traumatic stress disorder. The role of neural networks.
Neural networks and their behavior provide an information-processing model for initiation and maintenance of the biologic aspects of post-traumatic stress disorder (PTSD). The repeated replaying of the intrusive and distressing recollections that follow a trauma modifies the structure of the neural...
| Publicado en: | Psychiatric Clinics of North America Vol. 25; no. 2; pp. 253 - 272 |
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| Autores principales: | , , |
| Formato: | Journal Article |
| Publicado: |
W B Saunders
2002 Jun
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=105976986&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 105976986 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 0193953X 4G5 jtl: Psychiatric Clinics of North America issn: 0193953X maglogo: N pubinfo: dt: 2002 Jun vid: 25 iid: 2 pid: 1351 pub: W B Saunders place: Philadelphia, Pennsylvania artinfo: ui: 105976986 2009785159 NLM12136500 105976986 ppf: 253 ppct: 19 formats: tig: atl: Biologic models of traumatic memories and post-traumatic stress disorder. The role of neural networks. aug: au: McFarlane AC Yehuda R Clark CR sug: subj: Brain Physiopathology Memory Nervous System Physiology Stress Disorders, Post-Traumatic Physiopathology Animals Life Change Events Models, Biological ab: Neural networks and their behavior provide an information-processing model for initiation and maintenance of the biologic aspects of post-traumatic stress disorder (PTSD). The repeated replaying of the intrusive and distressing recollections that follow a trauma modifies the structure of the neural networks involved in the processing of traumatic memories. The hypothesis is proposed that this repetition instigates the mechanisms of iterative learning, top-down activation and pruning. The development of the symptoms of PTSD can be explained by current knowledge about modeling disturbances of parallel distributing processing. The noradrenergic neurons play a central role in coordinating the interaction of multiple cortical regions, which is an essential aspect of parallel distributed processing. Disturbances of this system in PTSD are likely to be manifest as a dysfunctional modulation of working memory and involuntary traumatic recollection. Modifications of neural networks have a secondary effect of kindling in the hippocampus that further moderates the individual's sensitivity to a range of stressors. Therefore, a neural network model of PTSD provides a method for conceptualizing the onset of PTSD symptoms and their subsequent modification with the passage of time.Copyright © 2002 by Elsevier Inc. pubtype: Academic Journal doctype: Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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